STAT1
Signal transducer and activator of transcription 1, also known as STAT1, is a transcription factor which in humans is encoded by the STAT1 gene.
Function
STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon-Stimulated Genes).
Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.
Interactions
STAT1 has been shown to interact with:
Leave On
Release date: 30. September 2002
Album: Happy Fool
LEAN ON
(verse)
How can I divide the time youÃve left me itÃs like infinity, this night it seems so long how can I devise what is ment to be if you wont set us free IÃm here to lean on when everythingÃs going wrong, girl, just hang on
(chorus)
When everything around you breaks the foundations you have made and IÃm the only one you can lean on just know if sometimes you rely on wrong I can right it make you strong and IÃm the only one you can lean on
(verse)
We must try and find a way to save this love just wishingÃs not enough the future itÃs calling us in that sweet sweet mind a promise I fulfilled and on that we can build IÃam here to lean on when everythings going wrong..........