Acadiana, or The Heart of Acadiana, (Cajun French: L'Acadiane) is the official name given to the French Louisiana region that is home to a large Francophone population. Of the 64 parishes that make up Louisiana, 22 named parishes and other parishes of similar cultural environment, make up the intrastate region.

The word Acadiana reputedly has two origins. Its first recorded appearance dates to the mid-1950s, when a Crowley, Louisiana, newspaper, the Crowley Daily Signal, coined the term in reference to Acadia Parish, Louisiana.

However, KATC TV-3 in Lafayette independently coined "Acadiana" in the early 1960s, gave it a new, broader meaning, and popularized it throughout south Louisiana. Founded in 1962, KATC was owned by the Acadian Television Corporation. In early 1963, the ABC affiliate received an invoice erroneously addressed to the Acadiana Television Corp. Someone had typed an extra "a" at the end of the word "Acadian." The station started using it to describe the region covered by its broadcast signal.