Dhamek Stupa (also spelled Dhamekh and Dhamekha) is a massive stupa located at Sarnath, 13 km away from Varanasi in the state of Uttar Pradesh, India.

The Dhamek Stupa was built in 500 CE to replace an earlier structure commissioned by the great Mauryan king Ashoka in 249 BCE, along with several other monuments, to commemorate the Buddha's activities in this location. Stupas originated as circular mounds encircled by large stones. King Ashoka built stupas to enshrine small pieces of calcinated bone and other relics of Buddha and his disciples. An Ashoka pillar with an edict engraved on it stands near the site.

The Dhamek Stupa is said to mark the spot of a deer park (Rishipattana) where the Buddha gave the first sermon to his five disciples after attaining enlightenment, "revealing his Eightfold Path leading to nirvana". The stupa was enlarged on six occasions but the upper part is still unfinished. While visiting Sarnath in 640 CE, Xuanzang recorded that the colony had over 1,500 priests and the main stupa was nearly 300 feet (91 m) high.