- published: 15 Aug 2013
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Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase. It is found in the bark of several species of plants, principally the white birch (Betula pubescens) from which it gets its name, but also the ber tree (Ziziphus mauritiana), selfheal (Prunella vulgaris), the tropical carnivorous plants Triphyophyllum peltatum and Ancistrocladus heyneanus, Diospyros leucomelas, a member of the persimmon family, Tetracera boiviniana, the jambul (Syzygium formosanum), flowering quince (Pseudocydonia sinensis, former Chaenomeles sinensis KOEHNE),rosemary, and Pulsatilla chinensis.
In 1995, betulinic acid was reported as a selective inhibitor of human melanoma. Then it was demonstrated to induce apoptosis in human neuroblastoma in vitro and in vivo in model systems. At one time, it was undergoing drug development with assistance from the Rapid Access to Intervention Development program of the National Cancer Institute. Also, betulinic acid was found active in vitro against neuroectodermal (neuroblastoma, medulloblastoma, Ewing's sarcoma) and malignant brain tumors,ovarian carcinoma, in human leukemia HL-60 cells, and malignant head and neck squamous cell carcinoma SCC25 and SCC9 cell lines. In contrast, epithelial tumors, such as breast, colon, small cell lung and renal cell carcinomas, as well as T-cell leukemia cells, were completely unresponsive to treatment with betulinic acid.
Hart may refer to:
Hart (Heart) is the fourth album by Dutch language rapper Brainpower. It was released April 21, 2008 on Lyric Recordings, together with his fifth album Hard (Hard) and contains the single "Eigen Werk" ("Own Work"). Hart and Hard are two albums sold together, where Hart represents the sensitive side of Brainpower with songs about his mother ("Ode Aan Me Mama" / "Ode To My Momma"), his father ("Zo Vader Zo Zoon" / "Like Father Like Son") and his girlfriend ("Als Jij Er Niet Bent" / "If You're Not Around" featuring his girlfriend Hind).
Hip Hop veteran Brainpower separates his more melodious material from his famous 'braggin' & boast' side.
Hart is based around themes like 'Anger', 'Fear', 'Hope', 'Pain' and 'Luck' and different sorts of love. The notion/word 'Hart' ('Heart') is the concept throughout. There are guest performances from Freek de Jonge, Hind and Candy Dulfer to DJs TLM and All Star Fresh.
* Only scratches.
Hart may refer to:
A short film directed by Mairin Hart. www.mairinhart.com
Directed by Mairin Hart Produced by No Roads Productions, The ATS Team, Olson Engage DP John Nodorft Editor John Norris Climbers/Influencers Natalie Duran, Norman Montes, Gibson Collins, Rachel Lannen, Leon Gittens, Sean Park
HIM Geo Louis Directed by: Mairin Hart Edited by: Casey Black Staring: Geo Louis, Michael Coghlan, Vanessa Wolf & Kaitlyn Nichols "HIM" Available on ITUNES! https://itunes.apple.com/us/album/him-single/id921915679
Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase. It is found in the bark of several species of plants, principally the white birch (Betula pubescens) from which it gets its name, but also the ber tree (Ziziphus mauritiana), selfheal (Prunella vulgaris), the tropical carnivorous plants Triphyophyllum peltatum and Ancistrocladus heyneanus, Diospyros leucomelas, a member of the persimmon family, Tetracera boiviniana, the jambul (Syzygium formosanum), flowering quince (Pseudocydonia sinensis, former Chaenomeles sinensis KOEHNE),rosemary, and Pulsatilla chinensis.
In 1995, betulinic acid was reported as a selective inhibitor of human melanoma. Then it was demonstrated to induce apoptosis in human neuroblastoma in vitro and in vivo in model systems. At one time, it was undergoing drug development with assistance from the Rapid Access to Intervention Development program of the National Cancer Institute. Also, betulinic acid was found active in vitro against neuroectodermal (neuroblastoma, medulloblastoma, Ewing's sarcoma) and malignant brain tumors,ovarian carcinoma, in human leukemia HL-60 cells, and malignant head and neck squamous cell carcinoma SCC25 and SCC9 cell lines. In contrast, epithelial tumors, such as breast, colon, small cell lung and renal cell carcinomas, as well as T-cell leukemia cells, were completely unresponsive to treatment with betulinic acid.
You stroll along
Retrace your footsteps
You see a child
He's left alone
Alone to stay
Alone with no one there to play
You recall your childhood
Still lonesome today
chorus
All he wanted was a friend
Someone he could talk to
Relate to
You attempt to reach
but then you look away
Nothing's accomplished
Two shadows fade
What to grow as?
What will you grow up to become?
Where are these answers?
Oh they'll come along
chorus
You wonder why you're still alone
You cry all night on your roof top
What are you hiding?
Is it something I must know?