Non Coding Rna

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So-called junk DNA plays critical role in mammalian development

Technology Org 22 Oct 2021

“If 50% of our genome is non-coding or repetitive — this dark matter — it is very tempting to ask the question whether or not human reproduction and the causes of human infertility can be explained by junk DNA sequences,” he said.

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Global RNA Analysis Market Research Report 2021 - ResearchAndMarkets.com

The Marshall News Messenger 21 Oct 2021

From large-scale analyses of the transcriptome - the whole collection of RNA transcripts encoded by a genome - to exploring the actions of individual short, non-coding RNAs on specific genes, RNA analysis research encompasses a wide range of issues.

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Interpace Diagnostics Announces US Patent Approval for Patent Application No. 11,118, 231 B2 ...

Kentucky New Era 21 Oct 2021

PARSIPPANY, NJ, Oct ... MicroRNAs are small, non-coding RNAs that bind to messenger RNA and regulate expression of proteins involved in human cancers, including thyroid cancer. ThyraMIR®, our micro-RNA classifier, is designed to work in concert with Interpace’s NGS based ThyGeNEXT® test to risk stratify indeterminate Thyroid nodules ... Contacts . ... .

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TransCode Therapeutics Appoints Zdravka Medarova, Ph.D., as Chief Technology Officer

The Marshall News Messenger 30 Sep 2021

Zdravka’s leadership will be invaluable as we pursue validation of our TTX platform as a viable means to bring the promise of RNA therapeutics to the treatment of cancer.” ... Medarova carried out seminal work in the field of RNA oncology ... Medarova has emerged as one of the leaders in the field of non-coding RNA delivery to cancer.

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Sequencing multiple RNA base modifications simultaneously: A new era of RNA biology

Phys Dot Org 29 Sep 2021

After a gene is transcribed into RNA, modifications can occur to the subunits or "bases" that make up the RNA molecule, which can affect its structure and function ... MicroRNAs are small non-coding RNA molecules that play a regulatory role by interfering with and suppressing the expression of a gene ... RNA modification may protect against liver disease.

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Revealing the molecular mechanism of nucleolar RNA

Phys Dot Org 27 Sep 2021

Feng Xuezhu from the First Affiliated Hospital of USTC, revealed the nucleolar RNA interference based on�Caenorhabditis elegans�(C ... siRNA is a kind of non-coding small RNA with a length of about 22 nucleotides ... risiRNAs complement rRNA sequences and regulate the level of rRNA by activating the nuclear RNA interference pathway.

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Abivax provides an update on the ABX464 clinical data and development strategy in ulcerative colitis

Pharmiweb 14 Sep 2021

Specifically, ABX464 enhances the selective splicing of a single long non-coding RNA to generate the anti-inflammatory microRNA, miR-124, which downregulates key pro-inflammatory cytokines and chemokines like TNF-α, IL-6, MCP-1 and IL-17, as well as Th17+ cells thereby "putting a ...

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Polymerase Chain Reaction Market Showcases Promising Growth Due to the Ongoing Demand and Improved Supply Chain Ecosystem

Pharmiweb 13 Sep 2021

Global Polymerase Chain Reaction Market ... Digital PCR (dPCR) is a novel method for detecting and quantifying nucleic acids ... The novel PCR equipment is intended for pathogen identification, gene expression analysis, SNP genotyping, variant identification, micro-RNA and other non-coding RNA assessment in clinical diagnostic laboratories ... Key Takeaways ... .

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Flamingo Therapeutics Expands Alliance with Ionis Pharmaceuticals to Develop RNA-targeted Therapies for Oncology

Citizen Tribune 09 Sep 2021

The agreement and discovery alliance will leverage Flamingo's deep expertise in oncology and long non-coding RNAs (lncRNAs) ... These scientific teams broke new ground on non-coding RNA genes in cancer and were among the first to show a role for lncRNAs as disease drivers in oncology.

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How Epigenetic Factors Play a Sizable Role in Bodily Health, According to Alexy Goldstein

The Signal 27 Aug 2021

Finally, non-coding RNA can attach to coding RNA to break it down and prevent the creation of new proteins ... For example, quitting smoking can increase DNA methylation of the AHRR gene, allowing former smokers to achieve similar genetic methylation levels as non-smokers in as little as a year.

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NIH-funded study discovers gene involved in male infertility

Technology Org 09 Aug 2021

The gene, PNLDC1, codes for an enzyme that processes a class of non-coding ribonucleic acids (RNA) so they can function. These non-coding RNAs are not involved in making proteins but are believed to be involved in various functions that occur during spermatogenesis — the process by which cells in the testes produce sperm cells.

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Global Epigenetics-Based Instruments Market 2021:Size,Demand, Upcoming Trends,Top Growing Companies 2026||Players-Eisai Co., Ltd.; Novartis AG; Diagenode s.a.; Zymo Research

Pharmiweb 09 Aug 2021

An international Epigenetics-Based Instruments market report defines CAGR value fluctuation during the forecast period of 2021-2028 for the market ... (DNA Methylation, Histone Methylation, Histone Acetylation, Large Non-Coding RNA, MicroRNA Modification, Chromatin Structures), ... (Oncology, Non-Oncology, Development Biology, Drug Discovery, Others), ... Tel.

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eFFECTOR Therapeutics Initiates Phase 2a Expansion Cohorts Evaluating Zotatifin in Breast ...

Tyler Morning Telegraph 04 Aug 2021

eIF4A is responsible for unwinding complex structures in the non-coding 5’ untranslated region of messenger RNA ... Since zotatifin inhibits the translation of mRNA by acting in the non-coding region of mRNAs, it is not limited to specific KRAS activating mutation subtypes such as KRAS G12C or KRAS G12D.

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Scientists boost gene knockdown in human cells with CRISPR-Cas13 using chemically modified guide RNAs

Phys Dot Org 03 Aug 2021

For non-coding elements in the human genome, targeting DNA may not be effective, and other organisms, such as RNA viruses like coronavirus or flu, cannot be targeted at all," said Sanjana, an assistant professor of biology at NYU, an assistant professor neuroscience and ...

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Testis-specific gene involved in sex ratio regulation discovered

Phys Dot Org 30 Jul 2021

One clear example of this are long non-coding RNA (lncRNA) molecules, which are a relatively new class of genes that are not translated into proteins yet directly fulfill intriguing functions. While many lncRNA genes have been identified, determining their specific purposes remains a challenge ... the regulation of sex ratios for offspring ... DOI ... Citation.