NPAS3
NPAS3 or Neuronal PAS domain protein 3 is a brain-enriched transcription factor belonging to the bHLH-PAS superfamily of transcription factors, the members of which carry out diverse functions, including circadian oscillations, neurogenesis, toxin metabolism, hypoxia, and tracheal development. NPAS3 contains basic helix-loop-helix structural motif and PAS domain, like the other proteins in the superfamily.
Function
NPAS3 is also known as human accelerated region 21. It may, therefore, have played a key role in differentiating humans from apes.
NPAS1 and NPAS3-deficient mice display behavioral abnormalities typical to the animal models of schizophrenia.
According to the same study, NPAS1 and NPAS3 disruption leads to reduced expression of reelin, which is also consistently found to be reduced in the brains of human patients with schizophrenia and psychotic bipolar disorder. Among the 49 genomic regions that undergone rapid changes in humans compared with their evolutionary ancestors, NPAS3 was found to be located in the region 21.
Podcasts:
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by Arctic Monkeys
No Buses
by: Arctic MonkeysLady, where has your love gone?
I was looking but can't find it anywhere
They always offer when there's loads of love around
But, when you're short of some, it's nowhere to be found
Well, I know your game, you told him yesterday
No chance, you'll get nothin' from me
But now she's there, you're there, everybody's there
He's in turmoil, as puzzled as can be
Just like me
Let's go down, down, low down
Where I know I should not go
Oh and she thinks she's the one
But she's just one in 24
And just 'cause everybody's doin' it
Does that mean that I can, too?
Lady, where has your love gone?
It was the anti-septic to the sore
To hold you by the hand
Must be first, be in demand
How he longs for you to long for him once more
Just once more
Let's go down, down, low down
Where I know I should not go
Oh and she thinks she's the one
But she's just one in 24
And just 'cause everybody's doin' it
Does that mean that I can, too? Oh...
Her eyes went down and cut you up
And there's nothing like a dirty look from
The one you want, or the one you've lost
An ache in your soul is everybody's goal
To get what they can't have
That's why you're after her
And that's why she's after him
But sayin' it wont change a thing
And they'll realise that it wont change a thing