Verapamil (brand names: Isoptin, Verelan, Verelan PM, Calan, Bosoptin, Covera-HS) is an L-type calcium channel blocker of the phenylalkylamine class. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and most recently, cluster headaches. It is also an effective preventive medication for migraine. Verapamil has also been used as a vasodilator during cryopreservation of blood vessels. It is a class IV antiarrhythmic, more effective than digoxin in controlling ventricular rate and was approved by the U.S. Food and Drug Administration (FDA) in March 1982.
Verapamil's mechanism in all cases is to block voltage-dependent calcium channels.
In cardiac pharmacology, calcium channel blockers are considered class IV antiarrhythmic agents. Since calcium channels are especially concentrated in the sinoatrial and atrio-ventricular nodes, these agents can be used to decrease impulse conduction through the AV node, thus protecting the ventricles from atrial tachyarrhythmias.
Inside the belly of a beast made of flesh and steel
My flesh and blood no longer seem so real
Inside this war machine that has blurred my sight
Distorting my vision of what's wrong or right
Blistering speed with a barrage of no mercy
Is the only thing fueling me to breathe
I am the future breed created through pure insanity
Simply shut off it I decide to think
I am the war machine
Forced to lead, bleed the weak
Lead by wicked hearts full of deceit
The war machine
Blistering speed with a barrage of no mercy
Is the only thing fueling me to breathe
I am the war machine
Forced to lead, bleed the weak
Lead by wicked hearts full of deceit
The war machine
All guns are locked and loaded
I am the weapon of mass destruction
This is the Armageddon of man
The time has come to unleash the master plan
Devastation and the ruins of man
Barren lands and blood soaked hands
Seek and destroy all survivors, nothing left but sand
I am the future breed created through pure insanity
Simply shut off it I decide to think
I am the war machine
Forced to lead, bleed the weak
Lead by wicked hearts full of deceit