Professional boxing, or prizefighting, emerged in the early twentieth century as boxing gradually attained legitimacy and became a regulated, sanctioned sport. Professional boxing bouts are fought for a purse which is divided between the boxers as determined by contract. Most professional bouts are supervised by a regulatory authority to guarantee the fighters' safety. Most high-profile bouts obtain the endorsement of a sanctioning body, which awards championship belts, establishes rules, and assigns its own judges and referee. Professional bouts are typically much longer than amateur bouts, and can last up to twelve rounds, though less significant fights can be as short as four rounds. Protective headgear is not permitted, and boxers are generally allowed to take substantial punishment before a fight is halted. Professional boxing has enjoyed a much higher profile than amateur boxing throughout the twentieth century and beyond.

In some countries, including Norway,Cuba and North Korea professional boxing is banned.