Sad Café

Sad Café may refer to:

See also

CAF

CAF or caf may refer to:

Armed forces

Computing and networking

Federations and organisations

Governmental organisations and projects

Cafú (footballer, born 1993)

Carlos Miguel Ribeiro Dias (born 26 February 1993), known as Cafú, is a Portuguese footballer who plays for Vitória Guimarães as a midfielder.

Club career

Born in Guimarães, Cafú had his first contact with football, in the youth ranks of his hometown club, Vitória Guimarães, which he would represent for two seasons. In 2008, he moved to Benfica, playing his first seasons as a defensive midfielder, then shifting to a striker role.

On 19 September 2012, Cafú made his debut with Benfica B in a 2012–13 Segunda Liga match against CD Tondela where he replaced Cláudio Correa at half-time, scoring the equalizer at 83rd minute.

On 26 July 2013, Cafú signed a four-year contract with Vitória Guimarães, returning to his hometown club after a five-year link to Benfica. At Guimarães he was immediately repositioned as defensive midfielder, being a usual starter in the miidfield of the reserve team, which earned promotion back to the Segunda Liga.

He made his debut in Primeira Liga on 17 August 2014, in a 3-1 win against Gil Vicente, partnering with André André and Bernard Mensah in the midfield, adding 29 appearances throughout the season in the first tier.

CAF-1

CAF-1 (chromatin assembly factor-1) is a complex, including Chaf1a (p150), Chaf1b (p60) and p50 subunits that assembles histone tetramers onto replicating DNA in vitro This complex is histone chaperone involved in creating cellular memory of somatic cell identity - cellular differentiation.

CAF-1 is required for the spatial organization and epigenetic marking of heterochromatin domains in pluripotent embryonic cells.

Cells resembling 2-cell-stage mouse embryos (totipotent cells) can be induced in vitro through downregulation of the chromatin-assembly activity of CAF-1 in embryonic stem cells.

Optimal modulation of both CAF-1 and transcription factor levels increases reprogramming efficiency by several orders of magnitude and facilitated iPS cell formation in as little as 4 days. Mechanistically, CAF-1 suppression led to a more accessible chromatin structure at enhancer elements early during reprogramming. These changes were accompanied by a decrease in somatic heterochromatin domains, increased binding of Sox2 to pluripotency-specific targets and activation of associated genes. Suppression of CAF-1 also enhance the direct conversion of B cells into macrophages and fibroblasts into neurons..

SWD Eagles

The South Western Districts Eagles are a South African rugby union team that participates in the annual Currie Cup and Vodacom Cup tournament. They represent the Southern Cape (Garden Route & Klein Karoo regions) and play out of Outeniqua Park in George.

History

The South Western Districts Rugby Football Union was established in 1899. Initially, home matches were held in Mossel Bay, Oudtshoorn and George, but in 1996, the SWDRFU made Outeniqua Park in George its home base.

They have never won the Currie Cup, but they did win the Bankfin Cup in 2002 and the Currie Cup First Division in 2007. They also reached the semi-finals of the Currie Cup in their centenary season in 1999 under Heyneke Meyer.

Sevens

The SWDRFU also hosted the South Africa Sevens leg of the IRB Sevens World Series for several seasons at Outeniqua Park. In 2012, they also launched the 7s Premier League tournament in 2012 held at the same venue.

Current squad

First team

The following players were included in the SWD Eagles squad for the 2015 Currie Cup First Division tournament:

Eagle (Middle-earth)

In J. R. R. Tolkien's fictional universe of Middle-earth, the eagles were immense flying birds that were sapient and could speak. Often emphatically referred to as the Great Eagles, they appear, usually and intentionally serving as agents of eucatastrophe or deus ex machina, in various parts of his legendarium, from The Silmarillion and the accounts of Númenor to The Hobbit and The Lord of the Rings. Just as the Ents are guardians of plant life, the giant eagles are the guardians of animal life.

These creatures are usually thought to have been similar to actual eagles (for example, as an independent species of the subfamily Buteoninae), but much larger. In The Silmarillion, Thorondor is said to have been the greatest of them and of all birds, with a wingspan of 30 fathoms (180 ft; 55 m). Elsewhere, the eagles have varied in nature and size both within Tolkien's writings and in later visualisations and films.

Appearances

The difference between "common" eagles and Great Eagles is prominently described in The Hobbit:

Eagles (2012 film)

Eagles is a 2012 Israeli drama film directed by Dror Sabo.

Cast

References

External links