As a means of recording the passage of time, the 15th century was the century which lasted from 1401 to 1500 Common Era.

Constantinople, the capital of the Eastern Roman Empire, falls to emerging Ottoman Turks, forcing Western Europeans to find a new trade route.

The Papacy was split in two parts in Europe for decades, until the Council of Constance.

Under the rule of Yongle Emperor, who built the Forbidden City and commanded Zhenghe to explore the world overseas, Ming Dynasty's territory reached pinnacle. Tamerlane established a major empire in the Middle East and Central Asia, in order to revive the Mongolian Empire. The Inca Empire rose to prominence in South America.

Spanish and Portuguese explorations led to the first European sightings of the Americas and the sea passage along Cape of Good Hope to India, in the last decade of the century. After these first sightings by Europeans, transportation increased to Europe from America. Native indigenous cultures that lived within the continent of the Americas had already developed advanced civilizations that attest to thousands of years of human presence; sophisticated engineering, irrigation, agriculture, religion and government existed before the arrival of the Spanish and the Portuguese. The idea that Europeans "discovered" America can lead to misunderstanding the true nature of the encounter between two distinct and independent civilizations, namely European and Indigenous American.

Zheng He (1371–1433; simplified Chinese: 郑和; traditional Chinese: 鄭和; pinyin: Zhèng Hé), also known as Ma Sanbao (simplified Chinese: 马三宝; traditional Chinese: 馬三寶) and Hajji Mahmud Shamsuddin (Arabic: حاجي محمود شمس الدين‎) was a Hui-Chinese mariner, explorer, diplomat and fleet admiral, who commanded voyages to Southeast Asia, South Asia, the Middle East, East Africa, and the Horn of Africa collectively referred to as the Voyages of Zheng He or Voyages of Cheng Ho from 1405 to 1433.

Zheng, born as Ma He (馬和 / 马和), was the second son of a Muslim family which also had four daughters, from Kunyang, present day Jinning, just south of Kunming near the southwest corner of Lake Dian in Yunnan.

He was the great great great grandson of Sayyid Ajjal Shams al-Din Omar, a Persian who served in the administration of the Mongolian Empire and was appointed governor of Yunnan during the early Yuan Dynasty. Both his grandfather and great-grandfather carried the title of Hajji, which indicates they had made the pilgrimage to Mecca. His great-grandfather was named Bayan and may have been a member of a Mongol garrison in Yunnan.