The A61 is a major trunk road in England. It runs from Derby to Thirsk in North Yorkshire. From Derby, it heads north via Alfreton, Clay Cross, Chesterfield, Sheffield, Barnsley, Wakefield, Leeds, Harrogate and Ripon. The road is closely paralleled by the M1 motorway as far as Leeds.

Heading south, the road begins as single carriageway which bypasses Ripon and onto Harrogate town centre. At Harrogate, the road divides into two major one way streets which enclose the town centre and run along The Stray, (a 200-acre (0.81 km²) stretch of grassland in Harrogate). The A61 continues through Harewood before approaching the north's metropolis, where a sudden urban fringe approaches. As the road enters Leeds, the road becomes a main dual carriageway (or Trunk Road) and artery for north Leeds. For a distance it stays the same before the arrival of the superbusway near Potternewton. Here, the A61 rises slightly, and a panoramic view of Leeds skyline is revealed. The descent into Leeds is quick and the road soon turns into a multi-lane road, as it approaches Sheepscar Interchange. Fast Flowing traffic is directed onto the A61, although some traffic is directed off the A61 to avoid Leeds City Centre as it routes around the back of Quarry House. The A61 meets it shortly after, as it shares the city centre loop for a short distance. After crossing the river, the road splits again before taking traffic out to the motorways. The road then continues out of Leeds towards Wakefield and Barnsley. South of Barnsley it crosses the M1 at Junction 36 then heads towards Sheffield. Between the M1 at Junction 36 and the Westwood roundabout intersection with the A616, the road is designated as a trunk road under the responsibility of the Highways Agency.