ERBB4

Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.

Function

Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment.

Clinical significance

Mutations in this gene have been associated with cancer. Other single-nucleotide polymorphisms and a risk haplotype have been linked to schizophrenia.Single-nucleotide polymorphisms in ERBB4 have also been found in a study of patients with familial Amyotrophic lateral sclerosis type 19

Calvin Harris

Adam Richard Wiles (born 17 January 1984), better known by his stage name Calvin Harris, is a Scottish DJ, singer, songwriter, record producer, recording artist and remixer. His debut album, I Created Disco, was released in 2007 and was the precursor to his top-10 singles "Acceptable in the 80s" and "The Girls". In 2009, Harris released his second studio album, Ready for the Weekend, which debuted at number one on the UK Albums Chart and earned a gold certification from the British Phonographic Industry within two months of release. Its lead single, "I'm Not Alone", became his first number one on the UK Singles Chart.

Harris rose to international prominence in 2012 with the release of his third studio album, 18 Months. Topping the UK charts, the album became his first to chart on the Billboard 200 in the US, reaching number 19. All eight of the album's singles; "Bounce", "Let's Go", "We'll Be Coming Back", "Sweet Nothing", "Drinking from the Bottle", "I Need Your Love", "Thinking About You" and "Feel So Close", along with "We Found Love" reached the top 10 of the UK Singles Chart.