- published: 25 Nov 2015
- views: 3030
Myc (c-Myc) is a regulator gene that codes for a transcription factor.
A mutated version of Myc is found in many cancers, which causes Myc to be constitutively (persistently) expressed. This leads to the unregulated expression of many genes, some of which are involved in cell proliferation and results in the formation of cancer. A common translocation involving Myc is t(8;14) which is critical to the development of most cases of Burkitt's Lymphoma. A recent study demonstrated that temporary inhibition of Myc selectively kills mouse lung cancer cells, making it a potential cancer drug target.
In the human genome, Myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). This means that in addition to its role as a classical transcription factor, Myc also functions to regulate global chromatin structure by regulating histone acetylation both in gene-rich regions and at sites far from any known gene.
Martin Seamus "Marty" McFly, Sr. is the protagonist in the Back to the Future film trilogy, and is portrayed by actor Michael J. Fox. Marty was also the protagonist in the animated series where he was voiced by David Kaufman. In the videogame by Telltale Games, he is voiced by AJ LoCascio.
Eric Stoltz was originally cast as Marty McFly, but after five weeks of shooting scenes for the first film, director Robert Zemeckis and executive producer Steven Spielberg chose to re-cast the role to Fox.
Marty was born in Hill Valley, California in 1968 to a family of Irish descent. Little is known about Marty's life prior to the first Back to the Future film, except for the fact that he accidentally set his parents' living room rug on fire when he was 8 (which we know from a statement of Marty's to his future parents).
In 1985, Marty plays lead guitar with his group The Pinheads and likes listening to Huey Lewis and the News, Tom Petty and the Heartbreakers, and Van Halen. He is also a talented skateboarder and proven to be an excellent shot with a gun, honed by endlessly playing shooting games such as Wild Gunman at his local 7-Eleven.
Myc (Swako) Exposed ( ͠° ͟ʖ ͡°)
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