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Latest News for: bcl6
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Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation [Immunology and Inflammation]
PNAS 03 Sep 2021
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Fertility and Sterility Publishes Largest Outcomes Research to Date on Cicero Diagnostic’s BCL6 Protein Test ...
Business Wire 03 Sep 2020
Cicero Diagnostics hosted the “Shared Experience Program” that collected the data. The objective of the rese .
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A high-resolution landscape of mutations in the BCL6 super-enhancer in normal human B cells [Medical Sciences]
PNAS 03 Dec 2019
Here we captured and sequenced 12 B cell SEs at... .
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BCL6 regulates brown adipocyte dormancy to maintain thermogenic reserve and fitness [Physiology]
PNAS 20 Aug 2019
Brown adipocytes provide a metabolic defense against environmental cold but become dormant as mammals habituate to warm environments ... Here, we identify B cell leukemia/lymphoma 6 (BCL6) as a critical regulator... .
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BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection [Immunology and Inflammation]
PNAS 11 Jun 2019
Neutrophils are vital for antimicrobial defense; however, their role during viral infection is less clear. Furthermore, the molecular regulation of neutrophil fate and function at the viral infected sites is largely elusive. Here we report that BCL6 deficiency in myeloid cells exhibited drastically enhanced host resistance to severe influenza A.. ...
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Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal ...
PNAS 07 May 2019
The IRF and Ets families of transcription factors regulate the expression of a range of genes involved in immune cell development and function. However, the understanding of the molecular mechanisms of each family member has been limited due to their redundancy and broad effects on multiple lineages of cells. Here,... .
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