- published: 14 Jan 2016
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Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.
IKK-α is a member of the serine/threonine protein kinase family and forms a complex in the cell with IKK-β and NEMO. NF-κB transcription factors are normally held in an inactive state by the inhibitory proteins IκBs. IKK-α and IKK-β phosphorylate the IκB proteins, marking them for degradation via ubiquitination and allowing NF-κB transcription factors to go into the nucleus.
Once activated, NF-κB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and cell proliferation.
Actors: Jacob Gregory (actor), Josekutty Valiyakallumkal (actor), Paulose Palatty (actor), George Kanatt (writer), George Kanatt (director), Jose Kadapuram (producer),
Genres: Comedy,Actors: Himani Shivpuri (actress), Avtar Gill (actor), Farida Jalal (actress), Rohini Hattangadi (actress), Sudhir Pandey (actor), Pramod Moutho (actor), Divya Dutta (actress), Tinnu Anand (actor), Amrit Pal (actor), Salman Khan (actor), Jack Gaud (actor), Saeed Jaffrey (actor), Kulbhushan Kharbanda (actor), Ganesh Acharya (miscellaneous crew), Adesh Shrivastava (composer),
Plot: Hawaldar found on illegal new born baby boy in the gutter of Kamathipura, a red light area of Bombay. A prostitute gives birth to a baby boy and she decides to educate him and request Hawaldar to give him father's name. Hawaldar's wife does not accept the child and leaves for her parent's home. Hawaldar adopts the child and names him as Ajay while the prostitute's son is named Shlok. Both are admitted to School while Shlok goes too far in studies and Ajay takes up gambling. Shlok falls in love with Pooja, daughter of J.K. a millionaire. Ajay does not believe in any relationship. Havaldar tries his best to get Ajay a job but Ajay finds that it is difficult for him to work of prevailing corruption in the society. Ekka Seth is a terror in sen workers basti and he exploits the innocent girl and forces them to adopt prostitution. Shlok graduates and completes M.B.A. Ajay wins a crore of rupees in gambling and tell Shlok to pursuer his project.Havaldar's own daughter is brought to his house by Ajay. Ekka and his men abduct her and kills her. Now Ajay decides to wipe out the terror of Ekka and free sen workers from the clutches of his men. He fights tooth and nail and at the cost of his life he eliminates Ekka and his empire. Sen workers are force to lead a honourable life in society.
Genres: Action,When I think of it now that it's done
How it might've gone without a place to belong
I can see we played into their hands
And they picked our bones until we proved them wrong
It's only a moment
The minutes and hours, they fly from me now as then
It's all in the detail
I've been here before but still don't remember when
As we stared in the face of the storm
And the change began to gather over the bend
There was always a chance it would come
But if you can't make it happen nobody can
It's all but forgotten
The minutes and hours, they're nothing that can't be
bought
It's all in the detail