ACE Inhibitors

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• published: 19 May 2015
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Here is a Video going over Ace Inhibitors! "Thumbs up" for more videos :) EmpoweRN.com Here is the page for the questions: http://empowern.com/2015/05/ace-inhibitors/ Disclaimer: These videos are intended for entertainment purposes only. Please follow the policy and procedures that your institution requires. Please note that the views, ideas & opinions expressed on this channel and in the videos on this channel are not necessarily of those of my employer or institution. The views expressed on this channel and in the videos channel do not represent medical advice. If you have specific medical concerns, please contact your physician. In order to protect patient privacy, all patient identifiers in all videos have been deleted or altered. The views expressed on this channel and in the videos on this channel are personal opinions. I am not an expert nor do I dispense medical advice or procedural specifications. The information I present is for general knowledge and entertainment purposes only. You need to refer to your own medical director, teachers and protocols for specific treatment information. It is your responsibility to know how best to treat your patient in your jurisdiction. I would like to thank the video contributors: Rizalyn Joy Gadugdug Maria Salvacion Gonzales Yasmin Hashmi Artem Shestakov And Babar Hayatrana Angiotensin-Converting Enzyme Inhibitors or commonly known as ACE Inhibitors. This pharmaceutical drug is used to treat congestive heart failure, high blood pressure and many other medical conditions. Research and clinical studies prove it to be a very effective drug class for many, as it works by causing the blood vessels to become enlarged or dilated, and thus causing a reduction in the blood pressure. This lowering of the blood pressure makes it easier for the heart to pump blood and it can improve the function of a failing heart. In the United States, 10 ACE inhibitors are in use: Ramipril (Altace) Enalapril (Vasotec, Epaned) Quinapril (Accupril) Captopril (Capoten) Benazepril (Lotensin) Lisinopril (Prinivil, Zestril) Fosinopril (Monopril) Moexipril (Univasc) Trandolapril (Mavik) Perindopril (Aceon) NOTE...that the brand names of all of these above end with the suffix “pril”. NOW.. let’s take a closer look at this drug class, angiotensin-converting enzyme (ACE) inhibitors, these drugs are helpful in treating heart, blood vessel, and kidney problems... Mechanism of Action: The human body is an amazing organism…In order to regulate water and blood pressure, our body follows special mechanisms. For example when the blood pressure drops too low, the kidneys release renin into the bloodstream. Renin then reacts with a protein called angiotensinogen that is produced by the liver. As a result, they form angiotensin I. Then another reaction converts angiotensin I to angiotensin II, with the help of angiotensin-converting enzyme found in the respiratory system. This whole mechanism is known as Renin-angiotensin system (RAS). Angiotensin II is a powerful substance. It circulates around the body in the bloodstream and induces several changes on the cardiovascular system. Such as stimulating adrenal cortex to release adolsterone and Constricting or narrowing down the blood vessels around the body. Aldosterone increases the reabsorption of water and sodium in the tubules of the kidneys. As a result, The volume of the blood and the concentration of salt in the blood increase leading to high blood pressure. The constriction of blood vessels results in high pressure inside the vessels, which also means an increase in blood pressure. Both of these events cause the heart to exert more pressure while pumping blood into the main arteries. Hence, it reverses the low blood pressure but it can also lead to other cardiovascular disorders if it persists for a long time. ACE inhibitors reduce the impact of renin-angiotensin-aldosterone system (RAAS) on the blood pressure by inhibiting the angiotensin converting enzyme. As a result, The conversion of angiotensin I to angiotensin II is slowed down which brings about several changes in the cardiovascular system. The rate of water reabsorption in the kidneys drops and so volume of blood decreases. And the blood vessels relax and become dilated. Both of these factors “reduce the work load on the heart,” (this phrase is a simple explanation that the nurse might give to her patient to explain how the ACE inhibitor Tags: nursing videos, youtube nursing videos, youtube nursing channel, videos for nurses, nursing videos, nursing pathophysiology videos, patho videos for nurses, med surg videos, medical surgical nurses, medical surgical videos, pharmacology videos, nursing pharmacology, nursing pharmacology videos, pharmacology, ace inhibitors, ace drugs, classes of drugs, review of drugs,