FTO gene

Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first mRNA demethylase that has been identified. Certain variants of the FTO gene appear to be correlated with obesity in humans.

Function

The amino acid sequence of the transcribed FTO protein shows high similarity with the enzyme AlkB which oxidatively demethylates DNA. Recombinant FTO protein was first discovered to catalyze demethylation of 3-methylthymine in single-stranded DNA, and 3-methyluridine in single-stranded RNA, with low efficiency. The nucleoside N6-methyladenosine, an abundant modification in RNA, was then found to be a major substrate of FTO. The FTO gene expression was also found to be significantly upregulated in the hypothalamus of rats after food deprivation and strongly negatively correlated with the expression of orexigenic galanin-like peptide which is involved in the stimulation of food intake.

Mitsubishi FTO

The Mitsubishi FTO, is a front engined, front-wheel drive coupe produced by Mitsubishi Motors between 1994 and 2000. It was originally planned to be exclusively for the Japanese domestic market, although its popularity as a grey market import to the United Kingdom, Ireland, and New Zealand led to eventual limited distribution through Mitsubishi's official dealers in those countries. Upon its debut it won the Car of the Year Japan award for 1994–95. In Japan, it was sold at a specific retail chain called Car Plaza.

FTO stands for "Fresh Touring Origination". The name recalls the Galant FTO coupé of 1971, one of the company's first sports cars.

Backstory: The Galant FTO (January 1971-1975)

Prior to the arrival of the 1994 front-wheel drive FTO, which inherited the 'FTO' tag, was the Mitsubishi Galant Coupé FTO. A rear-wheel drive coupe produced by Japanese automaker Mitsubishi Motors from November 1971 to March 1975.[1] "FTO" was meant to stand for Fresco Turismo Omologato, in a fine example of Japanese Italian (or 'Fresh Touring Origination' in English). This compact Coupé FTO can effectively be seen as a replacement for the earlier Mitsubishi Colt 11-F Super Sports.

FTO

FTO is a three letter acronym which can stand for: