The Zapotec language(s) are a group of closely related indigenous Mesoamerican languages spoken by the Zapotec people from the southwestern-central highlands of Mexico. Present-day native speakers are estimated to number over half a million, with the majority inhabiting the state of Oaxaca. Zapotec-speaking communities are also found in the neighboring states of Puebla and Guerrero. Emigration has also brought a number of native Zapotec-speakers to the United States, particularly in California. In most Zapotec-speaking communities, Spanish is also spoken.

The name of the language in Zapotec itself varies according to the geographical variant. In Juchitán (Isthmus) it is Diidxazá [didʒaˈza], in Mitla it is Didxsaj [didʒˈsaʰ], in Zoogocho it is Diža'xon [diʒaʔˈʐon], and in Santa Catarina Quioquitani it is Tiits Së [tiˀts sæ], for example. The first part of these expressions has the meaning 'word' (perhaps slightly reduced as appropriate for part of a compound).

Zapotec and the related language Chatino together form the Zapotecan subgroup of the Oto-Manguean language family. Zapotec languages (along with all Oto-Manguean languages) form part of the Mesoamerican Linguistic Area, an area of linguistic convergence developed throughout millennia of interaction between the peoples of Mesoamerica. As a result, languages have acquired characteristics from genetically unrelated languages of the area.