Endorphins ("endogenous morphine") are endogenous opioid peptides that function as neurotransmitters. They are produced by the pituitary gland and the hypothalamus in vertebrates during exercise,excitement, pain, consumption of spicy food, love and orgasm, and they resemble the opiates in their abilities to produce analgesia and a feeling of well-being.

The term implies a pharmacological activity (analogous to the activity of the corticosteroid category of biochemicals) as opposed to a specific chemical formulation. It consists of two parts: endo- and -orphin; these are short forms of the words endogenous and morphine, intended to mean "a morphine-like substance originating from within the body."

The term "endorphin rush" has been adopted in popular speech to refer to feelings of exhilaration brought on by pain, danger, or other forms of stress, supposedly due to the influence of endorphins. When a nerve impulse reaches the spinal cord, endorphins that prevent nerve cells from releasing more pain signals are released. Immediately after injury, endorphins allow animals to feel a sense of power and control over themselves that allows them to persist with activity for an extended time.^{[citation needed]}

Nick Douwma, better known by his stage name Sub Focus, is an English Electronic Music record producer. He has been releasing records since 2003. On 12 October 2009, he released his self-titled debut album. He plans to release a second album in 2012.

In March 2005 he had a number one single on the UK Dance Chart with "X-Ray / Scarecrow". The single reached number 60 on the UK Singles Chart. In June 2008, he hit number one on the UK Dance Chart again with "Timewarp / Join the Dots". In August 2009, he cracked the UK Top 40 for the first time with "Rock It / Follow the Light", which reached number 38. "Rock It / Follow the Light" also got him a third UK Dance Chart #1, as well as reaching the B-List of BBC Radio 1's playlist.

Sub Focus has also remixed selected works of The Prodigy, Deadmau5, Rusko, Dr. Octagon, Empire of the Sun and Dizzee Rascal.

On 6 October 2009, Sub Focus released "Smooth" which was free to download.

In 2010, Sub Focus was a support act for Australian drum & bass band Pendulum on their UK tour to promote their third album Immersion. Later that year, he produced the Example track "Kickstarts" for his second album, Won't Go Quietly. The track was successful in the UK Singles Chart, peaking at #3. This makes it Sub Focus' most commercially successful production to date.

Alexander George Clare (born 14 September 1985 in Southwark, London, England) is a British singer-songwriter. His debut album, The Lateness of the Hour, was released in the UK on 11 July 2011 on Island Records and was produced by Mike Spencer and Major Lazer.

Clare adopted his current stage name, Alex Clare, in 2010, replacing Alexander G. Muertos, a pseudonym he first used whilst still at school.

Clare was born in Southwark, London. He grew up listening to his father’s jazz records and was drawn to blues and soul (Donny Hathaway, Stevie Wonder), which eventually led to interests in drum and bass and UK garage. Though Clare took up the trumpet and drums as a youngster, he eventually placed an emphasis on guitar and songwriting, playing open mike nights with original material.^{[citation needed]}

A demo earned him a deal with the Island label in the UK. His debut album, The Lateness of the Hour, produced by Mike Spencer and Major Lazer was released in July 2011. The first single from the album was "Up All Night", followed by "Too Close" and "Treading Water".