Grand Sierra Resort & Casino is a resort hotel located approximately three miles east of Downtown Reno, Nevada. The hotel has 1,990 guest rooms and suites, 10 restaurants, including two by celebrity chef Charlie Palmer, and a casino with 100,000 square feet (9,300 m²) of space. The hotel also has a shopping center, wedding chapel, pool, convention center, 50-lane bowling alley, movie theater, a Lucky's Race & Sports Book, golfing and an RV park. The hotel announced in February 2011 that California based Meruelo Group will take over operations following a successful transaction from Credit Markets Real Estate. The ownership transfer was confirmed on April 1, 2011.

In 1975, officials from the Metro-Goldwyn Mayer Company began to scout out Reno locations for their proposed high rise hotel-casino they wanted to model after their very high profile Las Vegas casino, the MGM Grand. Following a deal with and approval from the City Council, MGM purchased land at the intersection of Mill and 2nd Streets, at that time a gravel pit. The Summer of 1976 saw construction begin on the 26 story, 1,015 room property that would then be one of the largest in the world. After two years of intense building, the building opened with fanfare, fashion and media attention on May 3, 1978. Rooms at the time were $35 for a standard to $250 for a suite. At its opening, the MGM Grand Reno featured a 100,000 sq ft (9,300 m²) casino floor, the world's largest 1800 seat Ziegfeld Theater, various ballrooms, seven restaurants, nineteen bars, two movie theaters, a bowling alley, a jai alai fronton, and an RV park.