The Agony in the Garden refers to the events in the life of Jesus between the Last Supper and Jesus' arrest.

Jesus' struggle (Greek agonia) praying and discussing with God, before accepting his sacrifice, before his arrest in the Garden of Gethsemane also denotes a state of mind - agony.

According to all four Gospels, immediately after the Last Supper, Jesus took a walk to pray (John 18:1). Matthew and Mark identify this place of prayer as Gethsemane. Jesus was accompanied by St. Peter, St. John and St. James the Greater, whom he asked to stay awake and pray. He moved "a stone's throw away" from them, where he felt overwhelming sadness and anguish, and said "My Father, if it is possible, let this cup pass me by. Nevertheless, let it be as you, not I, would have it." Then, a little while later, He said, "If this cup cannot pass by, but I must drink it, your will be done!" (Matthew 26:42). He said this prayer three times, checking on the three apostles, between each prayer and finding them asleep. He comments: "The spirit is willing, but the flesh is weak". An angel came from heaven to strengthen him. During his agony, as he prayed "his sweat was as it were great drops of blood falling down upon the ground".(Luke 22:44).