- published: 16 Jul 2014
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Conjugated linoleic acids (CLA) are a family of at least 28isomers of linoleic acid found mainly in the meat and dairy products derived from cud chewing mammals called ruminants. As the name implies, the double bonds of CLAs are conjugated, with only one single bond between them.
In 1979, researchers from the University of Wisconsin applied a beef extract to mice skin. The mice were then exposed to a strong carcinogen. When the researchers counted the number of tumors developed by the mice 16 weeks later, they found, to their surprise, that the mice exposed to the beef extract had 20% fewer tumors. The identity of this anticarcinogen was not discovered until almost a decade later, in 1987. Michael Pariza, the scientist who discovered CLA, later remarked that "few anticarcinogens, and certainly no other known fatty acids, are as effective as CLA in inhibiting carcinogenesis in these models." Although CLA is best known for its anticancer properties, researchers have also found that the cis-9, trans-11 form of CLA can reduce the risk for cardiovascular disease and help fight inflammation.
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