Tipping the scales on obesity and diabetes (The Jackson Laboratory)

Edit Public Technologies 28 Oct 2016
Shulman, professor of medicine and professor of cellular and molecular physiology; investigator, Howard Hughes Medical Institute; co-director, Yale Diabetes Research Center; director, Yale Mouse Metabolic Phenotyping Center....

The molecular mechanism that blocks membrane receptors involved in immunological response are identified (Euskal Herriko Unibertsitatea)

Edit Public Technologies 28 Oct 2016
(Source. Euskal Herriko Unibertsitatea). The study began by taking the medical history of 11 children, all of whom had a disorder due to mycobacteria infections, as the basis. All were discovered to have the same phenotype with the same mutation, which was located in the interferon-gamma (IFNGR) receptor, so the group began to explore what was causing this dysfunction ... Photos. Mikel Mtz. de Trespuentes. UPV/EHU ... (noodl. 36035752) ....

NIMH’s Francis McMahon, M.D., Awarded Prestigious Colvin Prize (NIMH - National Institute of Mental Health)

Edit Public Technologies 28 Oct 2016
(Source. NIMH - National Institute of Mental Health). The National Institute of Mental Health (NIMH) is pleased to announce that Francis McMahon, M.D., has been named a recipient of the Brain & Behavior Research Foundation's 2016 Colvin Prize for Outstanding Achievement in Mood Disorders Research. Dr ... Dr ... In addition to Dr ... His research focuses on the genotype-phenotype relationship in psychiatric disorders. Dr ... Med ... Dr ... Dr ... Dr ... Dr ... Dr ... (noodl....

Biogen’s Regulatory Applications for Nusinersen as a Treatment for Spinal Muscular Atrophy Accepted by FDA ...

Edit Stockhouse 28 Oct 2016
Biogen’s Regulatory Applications for Nusinersen as a Treatment for Spinal Muscular Atrophy Accepted by FDA and EMA. Nusinersen Granted Priority Review by FDA. EMA Plans to Follow Accelerated Assessment Timeline. Biogen (NASDAQ ... The regulatory review process for these applications has now been initiated in the U.S. and EU ... About SMA1-5 ... About Nusinersen ... Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2....

Biogen’s Regulatory Applications for Nusinersen as a Treatment for Spinal Muscular Atrophy Accepted by FDA and EMA (Biogen Idec Inc)

Edit Public Technologies 28 Oct 2016
(Source. Biogen Idec Inc). CAMBRIDGE, Mass.--(BUSINESS WIRE)--Biogen (NASDAQ. BIIB) today announced that its New Drug Application (NDA) for nusinersen, an investigational treatment for spinal muscular atrophy (SMA), has been accepted by the U.S ... The regulatory review process for these applications has now been initiated in the U.S. and EU ... About SMA ... 1 ... Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2....

Biogen’s Regulatory Applications for Nusinersen as a Treatment for Spinal Muscular Atrophy Accepted by FDA and EMA (Isis Pharmaceuticals Inc)

Edit Public Technologies 28 Oct 2016
(Source. Isis Pharmaceuticals Inc). Nusinersen Granted Priority Review by FDA. EMA Plans to Follow Accelerated Assessment Timeline. CAMBRIDGE, Mass.--(BUSINESS WIRE)--Oct. 28, 2016-- Biogen (NASDAQ ... Nusinersen had previously been granted Accelerated Assessment status by the EMA's Committee for Medicinal Products for Human Use (CHMP) ... and EU ... About SMA ... 1 ... Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2....

Cardiac role for SCN8A [Physiology]>

Edit PNAS 27 Oct 2016
Patients with early infantile epileptic encephalopathy (EIEE) are at increased risk for sudden unexpected death in epilepsy (SUDEP). De novo mutations of the sodium channel gene SCN8A, encoding the sodium channel Nav1.6, result in EIEE13 (OMIM 614558), which has a 10% risk of SUDEP. Here, we investigated the cardiac phenotype... ....

State’s Leading Institutions Launch International Effort to Advance Metabolic Research (University of Connecticut Health Center)

Edit Public Technologies 27 Oct 2016
Shulman, professor of medicine and professor of cellular and molecular physiology; investigator, Howard Hughes Medical Institute; co-director, Yale Diabetes Research Center; director, Yale Mouse Metabolic Phenotyping Center....

Genex to Debut New Dairy Health Traits (CRI - Cooperative Resources International Inc)

Edit Public Technologies 27 Oct 2016
(Source. CRI - Cooperative Resources International Inc). SHAWANO, Wisconsin -With the December sire summaries, Genex Cooperative, Inc ... Subclinical Ketosis ... Researchers with the CRI International Center for Biotechnology (ICB) then utilized the phenotypic data collected by AgSource from over 330,000 cows and a database of more than 100,000 genotypes from Genex males and females to develop the SCK breeding values. Metritis ... Foot Health ... ###....

Alexion Initiates Simultaneous Registration Trials of ALXN1210 for Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Atypical Hemolytic Uremic Syndrome (aHUS) (Alexion Pharmaceuticals Inc)

Edit Public Technologies 27 Oct 2016
(Source. Alexion Pharmaceuticals Inc). NEW HAVEN, Conn.--(BUSINESS WIRE)--Alexion Pharmaceuticals, Inc ... Both studies will evaluate ALXN1210 administered intravenously every eight weeks ... About the ALXN1210 PNH Study ... 1 ... 2 ... Relative Role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype ... Combined Complement Gene Mutations in Atypical Hemolytic Uremic Syndrome Influence Clinical Phenotype....

Alexion Initiates Simultaneous Registration Trials of ALXN1210 for Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) and ...

Edit Stockhouse 27 Oct 2016
Alexion Initiates Simultaneous Registration Trials of ALXN1210 for Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Atypical Hemolytic Uremic Syndrome (aHUS) ... Alexion Pharmaceuticals, Inc ... About aHUS ...   ... Relative Role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype ... Combined Complement Gene Mutations in Atypical Hemolytic Uremic Syndrome Influence Clinical Phenotype....

UON awarded over $5.6 million in NHMRC funding (University of Newcastle)

Edit Public Technologies 27 Oct 2016
(Source. University of Newcastle) ... With the help of this funding, our researchers aim to tackle a range of health-related issues that impact our communities ... Dr Emma Beckett is a molecular nutritionist who aims to explore the complex interactions that exist between the way we taste food (phenotype), genetic variance in taste receptors (genotype) and the bacteria that live in our guts (the gastrointestional microbiome) ... (noodl. 36009508) ....

Novel Concepts and Treatments in Cancer Cachexia (American College of Cardiology Foundation)

Edit Public Technologies 27 Oct 2016
(Source. American College of Cardiology Foundation). Background. Cancer-induced cachexia is an insidious, complex, paraneoplastic syndrome, affecting up to 50% of patients with cancer and the majority of patients with terminal cancer ... The variations in the spectrum of severity of cachexia have been attributed to variations in tumor phenotype or host genotype, thereby implying a role for the host-tumor interaction ... Clinical Significance....
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