- published: 14 Dec 2012
- views: 163151
Drug metabolism also known as xenobiotic metabolism is the biochemical modification of pharmaceutical substances or xenobiotics respectively by living organisms, usually through specialized enzymatic systems. Drug metabolism often converts lipophilic chemical compounds into more readily excreted hydrophilic products. The rate of metabolism determines the duration and intensity of a drug's pharmacological action.
Xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as drugs and poisons. These pathways are a form of biotransformation present in all major groups of organisms, and are considered to be of ancient origin. These reactions often act to detoxify poisonous compounds; however, in some cases, the intermediates in xenobiotic metabolism can themselves be the cause of toxic effects.
http://www.handwrittentutorials.com - This tutorial is the fourth in the Pharmacokinetics series. This tutorial discusses how drugs are metabolised by Cytochrome P450 enzymes. This tutorial covers Phase 1 and Phase 2 metabolism and gives a real world example. For more entirely FREE tutorials and the accompanying PDFs visit http://www.handwrittentutorials.com
Drug Metabolism - Phase 1 A video overview of Phase I metabolism & cytochrome P450 system (CYP450, P450). View the rest of my pharmacology videos in order below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw DRUG ABSORPTION Videos: (2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8 (3) Bioavailability: http://youtu.be/rv2Rpdi7OHM DRUG DISTRIBUTION Videos: (4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs (5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ ------------------ DRUG METABOLISM Videos: (6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k (7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M (8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE (9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw (10) Drug Half-life: http://youtu....
A media representation of a talk given by Dr. Roy Perlis. The purpose of the video is to provide a multimedia resource for improving health education.
Animated Video created using Animaker - http://www.animaker.com Phase I and Phase II metabolism in the liver
First Pass Metabolism: Definition and core concepts. Learn pharmacology with my other videos below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw DRUG ABSORPTION Videos: (2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8 (3) Bioavailability: http://youtu.be/rv2Rpdi7OHM DRUG DISTRIBUTION Videos: (4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs (5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ ------------------ DRUG METABOLISM Videos: (6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k (7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M (8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE (9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw (10) Drug Half-life: http://youtu.be/eTqPsqnbwoc (11) First-order elimination rate constant and h...
Check-out professor fink's web-site or additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.com Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased from the WLAC Bookstore at: https://wlac.redshelf.com/ “Hard Copy” Lecture Outlines can be purchased from the WLAC Bookstore at: http://onlinestore.wlac.edu/fink.asp
http://usmlefasttrack.com/?p=5025 reduction, oxidation, hydrolysis, conjugation, glucuronidation, acetylation, sulfaction, mnemonics: GAS Drug, Metabolism, -, Phase, I, and, Phase, 2, Findings, symptoms, findings, causes, mnemonics, review, what is, video, study, Rapid Review, Clinical presenation, First Aid, for, USMLE, Step 1, images, wiki, define, wikipedia, 2013, videos, exam, prep, easy, What is usmle, mnemonic, causes,
1. Explain the concept of drug half-life. 2. Compare and contrast steady-state, peak, trough, and duration. 3. Describe the process of absorption, including what enhances and what inhibits the process. 4. Discuss the impact of the "first pass effect on medication levels. 5. Outline the potential effects of taking multiple medications. 6. Compare and contrast the bioavailability of medications given by enteral, parenteral, topical, and inhalation routes. 7. List the impacts of chemical protein binding on medication availability and toxicity. Product ID: CLP037 Year: 2011 Duration: 21:00 minutes Other Programs Included in this Series: Pharmacology and the Healthcare Process Principles of Pharmacology Pharmacodynamics: What a Drug Does to the Body Please contact HEAT Inc., to purchase t...
This slideshow discusses the absorption, distribution, metabolism, and excretion of drugs.
http://www.handwrittentutorials.com - This tutorial is the fourth in the Pharmacokinetics series. This tutorial discusses how drugs are metabolised by Cytochrome P450 enzymes. This tutorial covers Phase 1 and Phase 2 metabolism and gives a real world example. For more entirely FREE tutorials and the accompanying PDFs visit http://www.handwrittentutorials.com
Drug Metabolism - Phase 1 A video overview of Phase I metabolism & cytochrome P450 system (CYP450, P450). View the rest of my pharmacology videos in order below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw DRUG ABSORPTION Videos: (2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8 (3) Bioavailability: http://youtu.be/rv2Rpdi7OHM DRUG DISTRIBUTION Videos: (4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs (5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ ------------------ DRUG METABOLISM Videos: (6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k (7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M (8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE (9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw (10) Drug Half-life: http://youtu....
A media representation of a talk given by Dr. Roy Perlis. The purpose of the video is to provide a multimedia resource for improving health education.
Animated Video created using Animaker - http://www.animaker.com Phase I and Phase II metabolism in the liver
First Pass Metabolism: Definition and core concepts. Learn pharmacology with my other videos below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw DRUG ABSORPTION Videos: (2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8 (3) Bioavailability: http://youtu.be/rv2Rpdi7OHM DRUG DISTRIBUTION Videos: (4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs (5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ ------------------ DRUG METABOLISM Videos: (6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k (7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M (8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE (9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw (10) Drug Half-life: http://youtu.be/eTqPsqnbwoc (11) First-order elimination rate constant and h...
Check-out professor fink's web-site or additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.com Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased from the WLAC Bookstore at: https://wlac.redshelf.com/ “Hard Copy” Lecture Outlines can be purchased from the WLAC Bookstore at: http://onlinestore.wlac.edu/fink.asp
http://usmlefasttrack.com/?p=5025 reduction, oxidation, hydrolysis, conjugation, glucuronidation, acetylation, sulfaction, mnemonics: GAS Drug, Metabolism, -, Phase, I, and, Phase, 2, Findings, symptoms, findings, causes, mnemonics, review, what is, video, study, Rapid Review, Clinical presenation, First Aid, for, USMLE, Step 1, images, wiki, define, wikipedia, 2013, videos, exam, prep, easy, What is usmle, mnemonic, causes,
1. Explain the concept of drug half-life. 2. Compare and contrast steady-state, peak, trough, and duration. 3. Describe the process of absorption, including what enhances and what inhibits the process. 4. Discuss the impact of the "first pass effect on medication levels. 5. Outline the potential effects of taking multiple medications. 6. Compare and contrast the bioavailability of medications given by enteral, parenteral, topical, and inhalation routes. 7. List the impacts of chemical protein binding on medication availability and toxicity. Product ID: CLP037 Year: 2011 Duration: 21:00 minutes Other Programs Included in this Series: Pharmacology and the Healthcare Process Principles of Pharmacology Pharmacodynamics: What a Drug Does to the Body Please contact HEAT Inc., to purchase t...
This slideshow discusses the absorption, distribution, metabolism, and excretion of drugs.
Check-out professor fink's web-site or additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.com Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased from the WLAC Bookstore at: https://wlac.redshelf.com/ “Hard Copy” Lecture Outlines can be purchased from the WLAC Bookstore at: http://onlinestore.wlac.edu/fink.asp
What are the differences between these two phases of drug biotransformation/metabolism?
Advanced review of drug metabolism
This is the Arabic-English version of a series of lectures in clinical pharmacology by Dr. AM Fouda. foudaamm@mans.edu.eg
فارما تيوب Pharma Tube هى سلسلة من الفيديوهات تحتوى على محاضرات فى علم الفارماكولوجى الأساسى والإكلينيكى يقدمها الصيدلى دهشان حسن دهشان الشرح من كتاب فارما جايد Pharma Guide Pharma Tube is a videos by Ph; Dahshan Hassan Dahshan containing lectures about basic and clinical pharmacology which prepared from Pharma Guide book ** الموضوعات الرئيسية لهذة الحلقة: ثلاثة أجزاء ******** الجزء الأول Metabolism - التعريف و Classification - شرح Phase I و Phase II - شرح Cytochrome P-450 (CYP450) - أنواع Metabolism Enzymes - Results of phase I metabolism - Factors Affecting Metabolism ******** الجزء الثانى Excretion - طرق خروج الدواء Routes of drug excretion - Method used to prolong duration of action of drugs ******** الجزء الثالث Pharmacokinetic Parameters 1) Bioavailability (BA 2) Volume of di...
Short lecture on the metabolism of xenobiotics in the context of foods and nutrition.
Physiologic changes associated with normal aging in relation to drug absorption, distribution, metabolism, and excretion.
الحلقة 4 من سلسلة التفاعلات الدوائية episode 4 of the drug interaction series --------------------------------------------------- in this episode we will discuss drug metabolism interactions --------------------------------------------------- presented by pharmacist : Ahmed Ibrahim Fahmy bachelor degree of pharmaceutical sciences Alexandria university - Egypt