R-spondin 4 is a protein in humans that is encoded by the RSPO4 gene. This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009].
R-spondin 2 also known as roof plate-specific spondin-2 is a protein that in humans that is encoded by the RSPO2 gene.
R-spondin 2 synergizes with Wnt to activate beta-catenin. RSPO2 has been proposed to regulate craniofacial patterning and morphogenesis within pharyngeal arch 1 through ectoderm-mesenchyme signaling via the endothelin-Dlx5/6 pathway.
In dogs, the Rspo2 gene determines hair growth.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
R-spondin-1 is a secreted protein that in humans is encoded by the Rspo1 gene, found on chromosome 1. In humans, it interacts with WNT4 in the process of female sex development. Loss of function can cause female to male sex reversal. Furthermore, it promotes canonical WNT/β catenin signaling.
The protein has two cysteine-rich, furin-like domains and one thrombospondin type 1 domain.
RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize β-catenin, which activates downstream targets. If both are deficient in XY mice, there is less expression of SRY and a reduction in the amount of SOX9. Moreover, defects in vascularization are found. These occurrences result in testicular hypoplasia. Male to female sex reversal, however, does not occur because Leydig cells remain normal. They are maintained by steroidogenic cells, now unrepressed.
"The Victims are what mean the most to us and that we cared so much about. And we're
Friends with, and had our classes with. I just really feel that we are going to be known as
The school that overcame."
(whoa) I know you're feelin' pain right now
(whoa) And you don't wanna talk right now
(whoa) I know you're going through something
And you don't want to be bothered right now (whoa)
Not gonna lie and say I understand
(whoa) I just wanna be here for you if I can
(whoa) To hold your hand and be by your side
And together we will get through these times
And we will cry together (uh huh)
And we'll fight this together (uh huh)
And we'll be strong together
Stand together
Pray together
Rise up
When you feel you cant go on
Rise up
And all of your hope is gone
Rise up
When you're weak and you cant be strong
Rise up (rise up)
Rise up
And when the tears start to fall
Rise up
And you feel you've given it your all
Rise up
When your back is up against the wall
Rise
Rise up
(whoa) Now I know the burdens that you bear
(whoa) And you don't think nobody cares
(whoa) A storm comes out of nowhere
And you feelin' like it just ain't fair (whoa)
Not here to preach about the brighter side (no)
Cause I understand and now is not the time (oh)
See I just want to help you make it right
Walk with you, holding up candle lights
And we will cry together (we will cry together)
And we'll fight this together (stand up and fight)
And we'll be strong together (hey)
Stand together (stand together)
Pray together
Rise up (woo)
When you feel you can't go on (feel like you can't go on)
Rise up
And all of your hope is gone (all your hope is gone)
Rise up
When you're weak and you can't be strong (hey
Rise (you gotta rise up yeah)
Rise up
And when the tears start to fall (yeah)
Rise up
And you feel you've given it your all
Rise up
When your back is up against the wall
Rise (rise)
You see struggle
Struggle has no color (hey)
No color (hey)
In the midst of crisis
You are my sister (hey) and I'm your brother (yeah)
And side by side we'll face this thing
Standin' tall (standin' tall)
You and me (hey)
Rise up
Rise
Rise up
Rise (Woo)
Rise up (Hey)
Rise
We will rise
Rise up
Heads up to the sky
Rise up
Rise
When all hope has fallen yeah
Rise up
We'll stand tall and believe (yes we will)
Rise
Rise up
And we gotta know tomorrow will come (yeah) and
Rise
Rise up
You will have the victory
Rise up
Hey Rise up Rise up
Rise
Rise up
Hey hey hey hey hey
Rise
Rise up
In the middle, in the middle of your storm when you, (rise up)
When you think you, when you think you cannot make it rise up
Rise up (ooh)
Rise
Rise up
God bless you Virginia. Our hearts go out to you and your families
Peace
R-spondin 4 is a protein in humans that is encoded by the RSPO4 gene. This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009].
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