- published: 24 Aug 2015
- views: 2982
A haplotype is, in the simplest terms, a specific group of genes or alleles that progeny inherited from one parent. There are, however, several specific definitions of the term being used in the field of genetics. First, it is a portmanteau word for haploid genotype, which is a collection of specific alleles (that is, specific DNA sequences) in a cluster of tightly-linked genes on a chromosome that are likely to be inherited together—that is, they are likely to be conserved as a sequence that survives the descent of many generations of reproduction.
A second specific meaning of the term haplotype: a set of single-nucleotide polymorphisms (SNPs) on one chromosome that tend to always occur together, i.e., that are associated statistically. It is thought that identifying these statistical associations and few alleles of a specific haplotype sequence can facilitate identifying all other such polymorphic sites that are nearby on the chromosome. Such information is critical for investigating the genetics of common diseases; which in fact have been investigated in humans by the International HapMap Project.
We've been invited to a cocktail party
Over by the palace wall
I've not been dressed up since my graduation
Haven't been around at all
Look what happens when you reach the top
The whole world is your oyster
You walk 'round like a bleeding fop
Meet me outside the curiosity shop
No need to bring money
Life can be so funny
When you're hangin' around with the hoi polloi
The countess wipes her nose upon her sleeve
Doesn't think that we can see
The duke of astinbury has to leave
He's afraid to dance with me
Look what happens when you've got it made
Everyone respects us
No more mingling with the local trade
As the hostess checks the sky for rain
Her fifteen year old daughter
Drives the patriarchal letch insane