In genetics, a mutagen (Latin, literally origin of change) is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level. As many mutations cause cancer, mutagens are therefore also likely to be carcinogens. Not all mutations are caused by mutagens: so-called "spontaneous mutations" occur due to spontaneous hydrolysis, errors in DNA replication, repair and recombination.
The first mutagens to be identified were carcinogens, substances that were shown to be linked to cancer. Tumors were described more than 2,000 years before the discovery of chromosomes and DNA; in 500 B.C., the Greek physician Hippocrates named crab-shaped tumors karkinos (from which the word "cancer" is derived via Latin), meaning crab. In 1567, Swiss physician Paracelsus suggested unidentified substance in mined ore (identified as radon gas in modern times) caused a wasting disease in miners, and in England, in 1761, John Hill made the first direct link of cancer to chemical substances by noting that excessive use of snuff may cause nasal cancer. In 1775, Dr. Percivall Pott wrote a paper on the high incidence of scrotal cancer in chimney sweeps, and suggested chimney soot as the cause of scrotal cancer. In 1915, Yamagawa and Ichikawa showed that repeated application of coal tar to rabbit's ears produced malignant cancer. Subsequently in the 1930s the carcinogen component in coal tar was identified as a polyaromatic hydrocarbon (PAH), benzo(a)pyrene. Polyaromatic hydrocarbons are also present in soot, which was suggested to be a causative agent of cancer over 150 years earlier.
Skies are crying, I am watching
Catching teardrops in my hands
Only silence, as it's ending, like we never had a chance.
Do you have to make me feel like there's nothing left of me?
You can take everything I have
You can break everything I am
Like I'm made of glass
Like I'm made of paper
And go on and try to tear me down
But I will be rising from the ground
Like a skyscraper, like a skyscraper
As the smoke clears
I awaken and untangle you from me
Would it make you feel better to watch me while I bleed
All my windows still are broken but I'm standing on my feet
You can take everything I have
You can break everything I am
Like I'm made of glass
Like I'm made of paper
And go on and try to tear me down
But I will be rising from the ground
Like a skyscraper, like a skyscraper
Go run run run, I'm gonna stay right here
Watch you disappear, yeah
Go run run run, yeah, it's a long way down
But I'm closer to the clouds up here
You can take everything I have
You can break everything I am
Like I'm made of glass
Like I'm made of paper
And go on and try to tear me down
But I will be rising from the ground
Like a skyscraper, like a skyscraper
Like a skyscraper, like a skyscraper
i know i can take one more steps towards you
cause all that's waiting is regret
and dont you know i'm not your ghost anymore
you lost the love i love the most
i learned to live half alive
and now you want me one more time
and who do you think you are
running round leaving scars
collecting your jar of hearts
and tearing love apart
you're gonna catch a cold
from the ice inside your soul
so dont come back for me
who do you think you are
i hear you're asking all around
if i am anywhere to be found
but i have grown too strong
to ever fall back in you arms
and i've learned to live half alive
and now you want me one more time
(repeat chorus)
and it took so long just to feel alright
remember how to put back the light in my eyes
i wish i had missed the first time that we kissed
cause you broke all your promises
and now you're back
you dont get to get me back
(repeat chorus)
(repeat chorus except last two words)
dont come back for me
dont come back at all
You were in college working part time waitin' tables
Left a small town, never looked back
I was a flight risk with a fear of fallin'
Wondering why we bother with love if it never lasts
I say "Can you believe it?
As we're lying on the couch?"
The moment I can see it.
Yes, yes, I can see it now.
Do you remember, we were sitting there by the water?
You put your arm around me for the first time.
You made a rebel of a careless man's careful daughter.
You are the best thing that's ever been mine.
Flash forward and we're taking on the world together,
And there's a drawer of my things at your place.
You learn my secrets and you figure out why I'm guarded,
You say we'll never make my parents' mistakes.
But we got bills to pay,
We got nothing figured out,
When it was hard to take,
Yes, yes, this is what I thought about.
Do you remember, we were sitting there, by the water?
You put your arm around me for the first time
You made a rebel of a careless man's careful daughter
You are the best thing that's ever been mine.
Do you remember all the city lights on the water?
You saw me start to believe for the first time
You made a rebel of a careless man's careful daughter
You are the best thing that's ever been mine.
Oh, oh, oh
And I remember that fight
Two-thirty AM
As everything was slipping right out of our hands
I ran out crying and you followed me out into the street
Braced myself for the "Goodbye"
'Cause that's all I've ever known
Then you took me by surprise
You said, "I'll never leave you alone."
You said, "I remember how we felt sitting by the water
And every time I look at you, it's like the first time
I fell in love with a careless man's careful daughter
She is the best thing that's ever been mine."
Hold on, make it last
Hold on, never turn back
You made a rebel of a careless man's careful daughter
You are the best thing that's ever been mine.
(Hold on) Do you believe it?
(Hold on) Gonna make it now.
(Hold on) I can see it,
I need another story
Something to get off my chest
My life gets kinda boring
Need something that I can confess
Til' all my sleeves are stained red
From all the truth that I've said
Come by it honestly I swear
Thought you saw wink, no
I've been on the brink, so
Oooh,
My god, amazing how we got this far
It's like we're chasing all those stars
Who's driving shiny big black cars
And everyday I see the news
All the problems that we could solve
And when a situation rises
Just write it into an album
Singing straight, too cold
I don't really like my flow, no, so
Tell me what you want to hear
Something that were like those years
Sick of all the insincere
So I'm gonna give all my secrets away
This time, don't need another perfect line
Don't care if critics never jump in line
I'm gonna give all my secrets away
Oh, got no reason, got not shame
Got no family I can blame
Just don't let me disappear
I'mma tell you everything
So tell me what you want to hear
Something that were like those years
Sick of all the insincere
So I'm gonna give all my secrets away
This time, don't need another perfect line
Don't care if critics never jump in line
I'm gonna give all my secrets away
Oooh, Oooh, Oh, Oh, Oh
All my secrets away
This time, don't need another perfect line
Don't care if critics never jump in line
I'm gonna give all my secrets away
There's a fire starting in my heart
Reaching a fever pitch,and it's bringing me out the dark
Finally I can see you crystal clear
Go head and sell me out and I'll lay your ship bare
See how I leave with every piece of you
Don't underestimate the things that I will do
There's a fire starting in my heart
Reaching a fever pitch
And it's bring me out the dark
The scars of your love remind me of us
They keep me thinking that we almost had it all
The scars of your love they leave me breathless
I can't help feeling
We could have had it all
Rolling in the deep
You had my heart inside your hand
And you played it
To the beat
Baby I have no story to be told
But I've heard one of you
And I'm gonna make your head burn
Think of me in the depths of your despair
Making a home down there
It Reminds you of the home we shared
The scars of your love remind me of us
They keep me thinking that we almost had it all
The scars of your love they leave me breathless
I can't help feeling
We could have had it all
Rolling in the deep
You had my heart inside your hand And you played it
To the beat
Throw your soul through every open door
Count your blessings to find what you look for
Turned my sorrow into treasured gold
You pay me back in kind and reap just what you sow
We could have had it all
We could have had it all
It all, it all it all,
We could have had it all
Rolling in the deep
You had my heart inside your hand
And you played it
Seems like everybody's got a price,
I wonder how they sleep at night.
When the tale comes first,
And the truth comes second,
Just stop, for a minute and
Smile
Why is everybody so serious!
Acting so damn mysterious
You got your shades on your eyes
And your heels so high
That you can't even have a good time.
[Pre-Chorus:]
Everybody look to their left (yeah)
Everybody look to their right (ha)
Can you feel that (yeah)
Well pay them with love tonight...
[Chorus:]
It's not about the money, money, money
We don't need your money, money, money
We just wanna make the world dance,
Forget about the Price Tag
Ain't about the (ha) Ka-Ching Ka-Ching.
Ain't about the (yeah) Ba-Bling Ba-Bling
Wanna make the world dance,
Forget about the Price Tag.
[Verse 2: Jessie J]
We need to take it back in time,
When music made us all UNITE!
And it wasn't low blows and video Hoes,
Am I the only one gettin... tired?
Why is everybody so obsessed?
Money can't buy us happiness
Can we all slow down and enjoy right now
Guarantee we'll be feelin
All right.
[Pre-Chorus:]
Everybody look to their left (yeah)
Everybody look to their right (ha)
Can you feel that (yeah)
I remember years ago
Someone told me I should take
Caution when it comes to love
I did, I did
And you were strong and I was not
My illusion, my mistake
I was careless, I forgot
I did
And now when all is done
There is nothing to say
You have gone and so effortlessly
You have won
You can go ahead tell them
Tell them all I know now
Shout it from the roof top
Write it on the sky love
All we had is gone now
Tell them I was happy
And my heart is broken
All my scars are open
Tell them what I hoped would be
Impossible, impossible
Impossible, impossible
Falling out of love is hard
Falling for betrayal is worst
Broken trust and broken hearts
I know, I know
Thinking all you need is there
Building faith on love is worst
Empty promises will wear
I know (i know)
And know when all is gone
There is nothing to say
And if you're done with embarrassing me
On your own you can go ahead tell them
Tell them all I know now
Shout it from the roof top
Write it on the sky love
All we had is gone now
Tell them I was happy
And my heart is broken
All my scars are open
Tell them what I hoped would be
Impossible, impossible
Impossible, impossible
Impossible, impossible
Impossible, impossible
Impossible, impossible
Ooh impossible (yeah yeah)
I remember years ago
Someone told me I should take
Caution when it comes to love
I did
Tell them all I know now
Shout it from the roof top
Write it on the sky love
All we had is gone now
Tell them I was happy (i was happy)
And my heart is broken
All my scars are open
Tell them what I hoped would be
Impossible, impossible
Impossible, impossible
Impossible, impossible
Impossible, impossible
Impossible, impossible
I remember years ago
Someone told me I should take
Caution when it comes to love
Last night I heard my own heart beating
Sounded like footsteps on my stairs
Six months gone and I'm still reaching
Even though I know you're not there
I was playing back a thousand memories, baby
Thinkin' 'bout everythin' we've been through
Maybe I've been goin' back too much lately
When time stood still and I had you
Come back, come back, come back to me like
You would, you would if this was a movie
Stand in the rain outside
'Til I came out
Come back, come back, come back to me like
You could, you could if you just said you're sorry
I know that we could work it out somehow
But if this was a movie you'd be here by now
I know people change and these things happen
But I remember how it was back then
Locked up in your arms and our friends were laughing
'Cause nothing like this ever happened to them
Now, I'm pacing down the hall, chasing down your street
Flashback to the night when you said to me
"Nothing's gonna change, not for me and you "
Not before I knew how much I had to lose
Come back, come back, come back to me like
You would, you would if this was a movie
Stand in the rain outside
'Til I came out
Come back, come back, come back to me like
You could, you could if you just said you're sorry
I know that we could work it out somehow
But if this was a movie you'd be here by now
If you're out there, if you're somewhere, if you're
moving on
I've be waiting for you ever since you've been gone
I just want it back the way it was before
And I just wanna see you back at my front door
And I say come back, come back, come back to me like
You would before you said it's not that easy
Before the fight, before I locked you out
But I'd take it all back now
Come back, come back, come back to me like
You would, you would if this was a movie
Stand in the rain outside
'Til I came out
Come back, come back, come back to me like
You could, you could if you just said sorry
I know that we could work it out somehow
But if this was a movie you'd be here by now
You'd be here by now
It's not the kind of ending you wanna see now
Baby, what about the ending?
Oh, I thought you'd be here by now
(originally by: The script, cover by: Maddi Jane)
I'm still alive, but I'm barely breathing
Just prayed to a God, that I don't believe in
Cause I got time, while he got freedom
Cause when a heart breaks, no it don't break even
His best days, were some of my worst
he finally met a girl, who's gonna put him first
While I'm wide awake, he's no trouble sleepin'
Cause when a heart breaks, no it don't break even
What am I gonna do
When the best part of me, was always you
And what am I supposed to say
When I'm all choked up, and you're okay yeah
I'm falling to pieces
I'm falling to pieces
They say bad things happen for a reason
but no wise words gonna stop the bleedin'
Cause he's moved on, while I'm still grieving
Cause when a heart breaks, no it don't break even
What am I gonna do
when the best part of me, was always you
And what am I supposed to say
When I'm all choked up, and you're okay yeah
I'm falling to pieces
I'm falling to pieces
I'm falling to pieces
I'm falling to pieces
You got his heart and my heart and none of the pain
You took your suitcase, and I took the blame
Now I'm tryin'a make sence of what little remains, oh
Cause you left me with no love
And no love to my name
I'm still alive, but I'm barely breathing
Just praying to a God that I don't believe in
Cause I got time, while he got freedom
Cause when a heart breaks, no it don't break even
No it don't break even no
And what am I gonna do
when the best part of me, was always you
And what am I supposed to say
When I'm all choked up, and you're okay yaeh
I'm falling to pieces
I'm falling to pieces, yeah yeah yeah
i'm falling to pieces, oh I'm falling to pieces
I know it's hard, I feel it too
so don't bother faking
It doesn't matter what troubles you
I will help you take it
Here from the rain, I shelter you
'Till the storm is ended
Fired as arrows, words untrue
But I defend this
Pitiful, you're so beautiful
and the line unfall on me
fall on me
Before the battle begins
and until it's through
I'm like a barricade in between anything in you
So how matter how far but
whatever it takes you will make it through the day
I'm your baricade
Before the battle begins
and until it's through
I'm like a barricade in between anything in you
So how matter how far but
whatever it takes you will make it through the day
I'm your baricade
Love is too real to a fairytale
so over after
Time is a healer, but I won't fail
to be with you faster
Pitiful, you're so beautiful
and the line unfall on me
unfall on me ...
Before the battle begins
and until it's through
I'm like a barricade in between anything in you
So how matter how far but
whatever it takes you will make it through the day
I'm your baricade
I-I-I'm your Barricade
I-I-I'm your Barricade
Barricade ..
I-I-I will be your Barricade
I'm your Barricade
It's a bombstuck you won't feel a thing
I can take it, you will make it through the day
I will be your Barricade
I will be your Barricade
I will be your Barricade
Before the battle begins
and until it's through
I'm like a barricade in between anything in you
So how matter how far but
whatever it takes you will make it through it
I'm your baricade ...
I-I-I'm your Barricade
I-I-I'm your Barricade
Barricade ..
I-I-I will be your Barricade
I remember years ago
Someone told me I should take
Caution when it comes to love
I did, I did
And you were strong and I was not
My illusion, my mistake
I was careless, I forgot
I did
And now when all is done
There is nothing to say
You have gone and so effortlessly
You have won
You can go ahead tell them
Tell them all I know now
Shout it from the roof top
Write it on the sky love
All we had is gone now
Tell them I was happy
And my heart is broken
All my scars are open
Tell them what I hoped would be
Impossible, impossible
Impossible, impossible
Falling out of love is hard
Falling for betrayal is worst
Broken trust and broken hearts
I know, I know
Thinking all you need is there
Building faith on love is worst
Empty promises will wear
I know (i know)
And know when all is gone
There is nothing to say
And if you're done with embarrassing me
On your own you can go ahead tell them
Tell them all I know now
Shout it from the roof top
Write it on the sky love
All we had is gone now
Tell them I was happy
And my heart is broken
All my scars are open
Tell them what I hoped would be
Impossible, impossible
Impossible, impossible
Impossible, impossible
Impossible, impossible
Impossible, impossible
Ooh impossible (yeah yeah)
I remember years ago
Someone told me I should take
Caution when it comes to love
I did
Tell them all I know now
Shout it from the roof top
Write it on the sky love
All we had is gone now
Tell them I was happy (i was happy)
And my heart is broken
All my scars are open
Tell them what I hoped would be
Impossible, impossible
Impossible, impossible
Impossible, impossible
Impossible, impossible
Impossible, impossible
I remember years ago
Someone told me I should take
Caution when it comes to love
Everyboyd's laughin' in the world
Rumors spreadin' 'bout this other girl
Do you do what did when you did with me
Does she love you the way I can
Did you forget all the plans that you made with me
'Cause baby I didn't
That should be me
Holdin' your hand
That should be me
Makin' you laugh
That should be me
This is so sad
That should be me
That should be me
That should be me
Feelin' your kiss
That should be me
Buyin' you gifts
This is so wrong
I can't go on
Until you believe that
That should be me
That should be me
You said you needed a little time
For my mistakes
Funny how you used that time
To have me replaced
Did you think that
I wouldn't see you
Out at the movies
What you're doin' to me
You're takin' her where we used to go
Now, if you're tryin' to break my heart
it's working 'cause you know
That should be me
Holdin' your hand
That should be me
Makin' you laugh
That should be me
This is so sad
That should be me
That should be me
That should be me
Feelin' your kiss
That should be me
Buyin' you gifts
This is so wrong
I can't go on
Until you believe that
That should be me
That should be me
I need to know: Should I fight for love,
Or disarm?
It's getting harder to shield
The pain in my heart
That should be me
Holdin' your hand
That should be me
Makin' you laugh
That should be me
This is so sad
That should be me
That should be me
That should be me
Feelin' your kiss
That should be me
Buyin' you gifts
This is so wrong
I can't go on
Until you believe that
That should be me
That should be me
Holding your hand
Oh, and makin' you laugh
Oh, baby
That should be me, oh
Givin' you flowers
Talking for hours
Yeah
That should be me
I never shoulda let you go
I never shoulda let you go
I never shoulda let you go, oh