DMT

DMT may refer to the following:

Chemical substances

Sports

Other uses

2,alpha-DMT

2,alpha-DMT, or 2,α-dimethyltryptamine, is a tryptamine and a lesser-known psychedelic drug. It is the 2,a-dimethyl analog of DMT. 2,α-DMT was first synthesized by Alexander Shulgin. In his book TiHKAL (Tryptamines I Have Known and Loved), Shulgin lists the dosage as 300-500 mg, and the duration as 7-10 hours. 2,α-DMT causes mydriasis and paresthesia. It also produces a calm, drunk-like feeling. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2,α-DMT.

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External links

DMT1

The divalent metal transporter 1 (DMT1), also known as natural resistance-associated macrophage protein 2 (NRAMP 2), and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2) gene. DMT1 represents a large family of orthologous metal ion transporter proteins that are highly conserved from bacteria to humans.

As its name suggests, DMT1 binds a variety of divalent metals including cadmium (Cd²⁺), copper (Cu²⁺), and zinc (Zn^2+,,) however it is best known for its role in transporting ferrous iron (Fe²⁺); DMT1 expression is regulated by body iron stores to maintain iron homeostasis. DMT1 is also important in the absorption and transport of manganese (Mn²⁺). In the digestive tract, it is located on the apical membrane of enterocytes, where it carries out H⁺ coupled transport of divalent metal cations from the intestinal lumen into the cell.

Role in neurodegenerative diseases

Toxic accumulation of divalent metals, especially iron and/or manganese, are frequently discussed aetiological factors in a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. DMT1 may be the major transporter of manganese across the blood brain barrier and expression of this protein in the nasal epithelium provides a route for direct absorption of metals into the brain. DMT1 expression in the brain may increase with age, increasing susceptibility to metal induced pathologies. DMT1 expression is found to be increased in the substantia nigra of Parkinson's patients and in the ventral mesencephalon of animal models intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) - a neurotoxin widely used experimentally to produce Parkinsonian symptoms.

Adventure

An adventure is an exciting or unusual experience. It may also be a bold, usually risky undertaking, with an uncertain outcome. Adventures may be activities with some potential for physical danger such as exploring, skydiving, mountain climbing, river rafting or participating in extreme sports. The term also broadly refers to any enterprise that is potentially fraught with physical, financial or psychological risk, such as a business venture, a love affair, or other major life undertakings .

Motivation

Adventurous experiences create psychological arousal, which can be interpreted as negative (e.g. fear) or positive (e.g. flow), and which can be detrimental as stated by the Yerkes-Dodson law. For some people, adventure becomes a major pursuit in and of itself. According to adventurer André Malraux, in his La Condition Humaine (1933), "If a man is not ready to risk his life, where is his dignity?". Similarly, Helen Keller stated that "Life is either a daring adventure or nothing."

Adventures (album)

Adventures is the eighth studio album by Japanese Jazz fusion band T-Square, who was then known as The Square. It was released on April 1, 1984.

Track listing

Sources

References

Speedin' Bullet 2 Heaven

Speedin' Bullet 2 Heaven is the fifth studio album by American recording artist Kid Cudi. The album was released on December 4, 2015, through Republic Records and Cudi's Wicked Awesome Records imprint. The album is a complete departure from his previous projects, excluding WZRD, a 2012 collaborative effort which was his first venture into rock music. Inspired by the 1990's indie music scene, Cudi included commissioned skits featuring Mike Judge voicing the titular characters of his 90's animated sitcom, Beavis and Butt-Head.

Speedin' Bullet 2 Heaven, described by Cudi as alternative music, is the follow-up to his 2014 digital release, Satellite Flight: The Journey to Mother Moon. Serving as a double disc effort, the album comes with 26 tracks in total, with the actual album on Side A containing 18, while Side B is composed of eight tracks, which are mostly demos and outtakes. The album, primarily produced by Cudi himself, was supported by two official singles, "Confused!" and the title-track "Speedin' Bullet 2 Heaven".