Alsace wine or Alsatian wine (in French: Vin d'Alsace) is produced in the Alsace region in France and is primarily white. These wines, which for historical reasons have a strong Germanic influence, are produced under three different Appellations d'Origine Contrôlées (AOCs): Alsace AOC for white, rosé and red wines, Alsace Grand Cru AOC for white wines from certain classified vineyards and Crémant d'Alsace AOC for sparkling wines. Both dry and sweet white wines are produced, and are often made from aromatic grapes varieties. Along with Austria and Germany, it produces some of the most noted dry Rieslings in the world, but on the export market, Alsace is perhaps even more noted for highly aromatic Gewürztraminer wines. Because of its Germanic influence, it is the only region in France to produce mostly varietal wines, typically from similar grapes as used in German wine.

In 2006, vines were grown on 15,298 hectares (37,800 acres) in 119 villages in Alsace, and 111.3 million litres of wine was produced, corresponding to 148.4 million bottles of 750 ml, generating 478.8 million euro in revenue. Of the vineyard surface, 78% was classified for the production of AOC Alsace wines, 4% for AOC Alsace Grand Cru and 18% for AOC Crémant d'Alsace. About 90% of the wine produced is white. 25% of the production is exported, and the five largest export markets for still Alsace wine in terms of volume are Belgium, Netherlands, Germany, Denmark and the United States.

Alsace (French: Alsace [alzas]; Alsatian: Elsàss [ˈɛlsɑs]; German: Elsass, pre-1996: Elsaß, IPA: [ˈɛlzas]; Latin: Alsatia) is the fifth-smallest of the 27 regions of France in land area (8,280 km²), and the smallest in metropolitan France. It is also the seventh-most densely populated region in France and third most densely populated region in metropolitan France, with ca. 220 inhabitants per km² (total population in 2006: 1,815,488; 1 January 2008 estimate: 1,836,000). Alsace is located on France's eastern border and on the west bank of the upper Rhine adjacent to Germany and Switzerland. The political, economic and cultural capital as well as largest city of Alsace is Strasbourg. Because that city is the seat of dozens of international organizations and bodies, Alsace is politically one of the most important regions in the European Union.

The name "Alsace" can be traced back to the Old High German Ali-saz or Elisaz, meaning "foreign domain". An alternative explanation derives it from a Germanic Ell-sass, meaning "seated on the Ill", a river in Alsace. The region was historically part of the Holy Roman Empire. It was gradually annexed by France in the 17th century under kings Louis XIII and Louis XIV and made one of the provinces of France. Alsace is frequently mentioned in conjunction with Lorraine, because German possession of parts of these two régions (as the imperial province Alsace-Lorraine, 1871–1918) was contested in the 19th and 20th centuries, during which Alsace changed hands four times between France and Germany in 75 years.