- published: 13 Sep 2013
- views: 37449
An osteoclast (from the Greek words for "bone" (ὀστέον), and "broken" (κλαστός)) is a type of bone cell that breaks down bone tissue. This function is critical in the maintenance, repair, and remodelling of bones of the vertebral skeleton. The osteoclast disassembles and digests the composite of hydrated protein and mineral at a molecular level by secreting acid and a collagenase, a process known as bone resorption. This process also helps regulate the level of blood calcium.
Osteoclasts were discovered by Kolliker in 1873. An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have five nuclei and are about 150-200 µm in diameter. Giant osteoclasts can occur in some diseases, including Paget's disease of bone and bisphosphonate toxicity. When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 µm in diameter occur. These may have dozens of nuclei, and typically express major osteoclast proteins but have significant differences from cells in living bone because of the not-natural substrate. The size of the multinucleated assembled osteoclast allows it to focus the ion transport, protein secretory and vesicular transport capabilities of many macrophages on a localized area of bone.
Educational video describing Osteoclast / Osteoblasts bone absorption and remodeling. Become a friend on facebook: http://www.facebook.com/drebraheim Follow me on twitter: https://twitter.com/#!/DrEbraheim_UTMC
The second film in the bone biology series describes the role and functions of the cells responsible for breaking down bone tissue (osteoclasts) and building new bone (osteoblasts).
This fourth film in our bone biology series focuses on the link between the protein RANK ligand and how it signals the process of bone tissue breakdown.
Osteoclast monster legends, osteoclast level 1 to 100 and combat in pvp, monster legends guide. ► Facebook: https://www.facebook.com/john.harry.3386585 ► Fanpage : https://www.facebook.com/monstergames123 ► Twitter: https://twitter.com/tutranlegends ► Blogger : http://monstergame123.blogspot.com/ ► Playlist monster legends : https://www.youtube.com/watch?v=m6qpOMAhAT0&list;=PL4wfjxf3bNcpw1ALV-FynkxyPIS3BaxSD ► Playlist combat : https://www.youtube.com/watch?v=VQ2uYXY4buM&list;=PL4wfjxf3bNcqErxv-yQ3Xlg1DiqOtR4LC ► Playlist Legendary : https://www.youtube.com/watch?v=ZDrgUf5lTco&list;=PL4wfjxf3bNcouzCUkYqNpQQkAU7ISYXrF See some of my other related videos: ► Vanoss: https://youtu.be/AnH5Feh1YJU ► Cyan nathura: https://youtu.be/jnmdxkpMXj4 ► Dr. Hazard Review: https://youtu.be/utRSP-pxD90 ► Comb...
Osteoblast Vs Osteoclast Vs Osteocyte
Structure of the Osteoclast, Frcs orth revision
Medaka fish in the Aquatic Habitat (AQH) just after transferred from the fish transportation container launched by Soyuz TMA-26a to the AQH. Day 1 / Day 8 / Day 13 / Day 21 - Medaka fish in the AQH located in the Kibo Module are fed by the automatic feeder.