- published: 15 Sep 2016
- views: 4605
Rac1, also known as Ras-related C3 botulinum toxin substrate 1, is a protein found in human cells. It is encoded by the RAC1 gene. This gene can produce a variety of alternatively spliced versions of the Rac1 protein, which appear to carry out different functions.
Rac1 is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.
Rac1 is a pleiotropic regulator of many cellular processes, including the cell cycle, cell-cell adhesion, motility (through the actin network), and of epithelial differentiation (proposed to be necessary for maintaining epidermal stem cells).
Along with other subfamily of Rac and Rho proteins, they exert an important regulatory role specifically in cell motility and cell growth. Rac1 has ubiquitous tissue expression, and drives cell motility by formation of lamellipodia. In order for cancer cells to grow and invade local and distant tissues, deregulation of cell motility is one of the hallmark events in cancer cell invasion and metastasis. Activating or gain-of-function mutations of Rac1 are shown to play active roles in promoting mesenchymal-type of cell movement assisted by NEDD9 and DOCK3 protein complex. Such abnormal cell motility may result in epithelial mesenchymal transition (EMT) – a driving mechanism for tumor metastasis as well as drug-resistant tumor relapse.
---------------------------------------DESCRIPCIÓN VÍDEO---------------------------------- ✔ La emisora de radio catalana RAC1 narró de esta manera el gol de Morata que culminaba la remontada del Real Madrid ante el Sporting de Portugal en el último minuto del partido. ✔ SONG: ----------------------------------------REDES SOCIALES--------------------------------------- ✔ SUSCRÍBETE: https://www.youtube.com/user/ElDiaDespues12Plus ✔ TWITTER: https://twitter.com/ElDiaDespues12P ✔ GOOGLE+: https://plus.google.com/+ElDiaDespues12Plus ✔ EMAIL: eldiadespues12@gmail.com ----------------------------✌✌✌LIKE, COMPARTE & SUSCRÍBETE✌✌✌----------------------
Tanda de penaltis de la final de la UEFA Champions League narrada por RAC1. Twitter: RM_Pictures
La emisora de radio catalana RAC1 narró el gol que daba el título al Real Madrid frente al Sevilla de manera desinteresada.
Como no podia ser de otra manera, no tiene desperdicio
la ramatada y al gal
Gracias al gran apoyo que tuvo el ultimo video de nuestros amigos de RAC1 narrando los penaltis de la final, aqui teneis el penalti errado de Antoine Griezmann. #Bilis
Yeah, yeah, hey, hey hey
R.I.P. Pooh Bear, that's my dead homie
Fuck that other shit, hey, let's get this bread homie
Remember when they could catch a charge down in Atlanta
They underestimate me 'cause I'm comin' from Alabama
Martin Lee Anderson, he ain't even have a chance
They beat him in that boot camp 'til he died in that ambulance
That boy was only fifteen years old, fuck what they say he did
So tell me how I'm 'posed to feel when police killin' kids?
And then we can't get a job, ridin' we get them pounds
If it ain't that coke then we get that 'dro and break it down
See that ice, the dope man paradise
Boy better think twice, that dope have you doin' life
They tore down the projects, so where we gon' move next?
They takin' them food stamps, they stop government checks
Hey, money my motivator, my mouth my money maker
Naw I don't see them haters, so let's go get this paper
Yeah when you look at us just think about it, we don't own nothin'..
If we get money, we got a lil' few dollars, but our whole family tore up nigga
you gettin' money for the people in ya family that ain't got nothin'..
When it's all said and done, what do you own? You don't own nothin', you
don't own you... The nigga playin' basketball, he don't own that jersey, he can't
even be in a commercial wit' his name on the back, so when it's really all
said and done, what did you do this for? What difference did you make?
You see how the world changin'? Yeah, they look so dumb ain't it?
Wish they just kill 'em all so now the Middle East they bangin'
Preachers in that pulpit, say they teach that bullshit
So know how we know it's bullshit? Same niggas I went to school wit'
Grabbin' on yo' nuts and disrespectin' get you merked
Them young niggas got pistol grips, they been about they killin' shit
But they all some hypocrites, haters they won't let me be
When I come up to them gates, I hope you say you heard of me
Now Kendrick Curtis gone, them angels took him home
They gave my brother ten years, the system did him wrong
Now we convicted felons, because they caught us sellin'
And nine times out of ten yo' friend the one who tellin'
I wanna go to Heaven, up to that Promised Land
I need another chance, I wanna meet that man
Money my motivator, my mouth my money maker
No I don't see you haters, so let's go get this paper
Yeah! Surprise niggas! Hey we ?? nigga! Everybody talkin' 'bout they gettin'
money... Y'all niggas ain't gettin' no muthafuckin' money nigga! I got
millions nigga and I'm still broke nigga 'cause that ain't no mutafuckin' money!
Y'all playin' right into these muthafuckin' hands... Risk ya life
everyday for some bullshit! Huh nigga? What yo' bank account say nigga?
Oh that's all? Haha!
They shippin' them boys off, they fightin' in Iraq
It's soldiers in that war that ain't never gon' make it back
Niggas this the battlefield, fake niggas scream keep it real
Yeah yeah, rob, steal, anything to pay them bills
Hey nigga times harder, so we grind harder
We takin' chances wit' that coke comin' 'cross that water
Tryin' to get up out this ghetto life ain't gotta be this way
Them pigs they came and kicked my mama do' in yesterday
I prayed a thousand nights, I did a hundred crimes
And now I'm beggin' Lord that you don't let me down this time
Money my motivator, my mouth my money maker
No I don't see them haters, so let's go get this paper
Our Father who art in Heaven, Please Lord forgive me for that crack
sellin'... Thou kingdom come, thou will be done, these niggas dumb
Yeah nigga gave my brother ten years nigga... what the
fuck you s'posed to do wit' that nigga they gave my uncle twenty years nigga..
matter fact they gave my cousin life nigga... I can tell ya how I feel nigga
be on that muthafuckin' stand nigga lookin' the muthafuckin' judge in they
face nigga... and he gon' tell you some stupid shit like "life" nigga..
They sendin' y'all niggas on vacation nigga 'cross the nation nigga, y'all
niggas caught up in the muthafuckin' hype nigga... Sellin' that white
nigga... I been there, done that nigga Nigga I'm from Mobile nigga they call that
bitch ?? city nigga, you bring yo' black ass there nigga, you ain't gon' make it
nigga... You guaranteed to go to muhfuckin' prison bein' black where I'm from
nigga I come from the mutafuckin' impossible nigga Now y'all niggas gotta
deal wit' me nigga I'm here! Zone 4 new muthafuckin' money nigga D Boy Squad..