The A64 is a major road in North and West Yorkshire, England which links Leeds, York and Scarborough. The A64 starts as the A64(M) ring road motorway in Leeds, then towards York it becomes a high quality dual carriageway for the remainder of its route, except sections of the road from Malton to Scarborough.

The road approximates a section of the old Roman road running from Chester to Bridlington, intersecting Ermine Street - the Old North Road - at York.

The road begins in Leeds as the A64(M) at Richmond Hill and the Woodpecker Junction, and close to the West Yorkshire Playhouse and the NHS's imposing Quarry House. It leads onto the York Road, passing All Saints Richmond Hill CE Primary School where there is a flyover for Lupton Avenue, and a left turn for the B6159 Harehills Lane near the Victoria Primary School. At Killingbeck, the A63 forks to the right at its western terminus. It passes Asda on the left, with the Killingbeck Retail Park, and Seacroft Hospital on the right. It meets Foundry Lane and Cross Gates Road at a roundabout next to Killingbeck police station. It meets, and overlaps with, the Leeds Outer Ring Road (A6120) at a roundabout near Swarcliffe next to St Theresa's RC Primary School, and at Seacroft there is a roundabout where the A64 leaves to the right, with the Ramada Leeds North hotel to the east.