Imidazole is an organic compound with the formula (CH)2N(NH)CH. It is a colourless solid that dissolves in water to give mildly basic solution. In chemistry, it is an aromatic heterocycle, classified as a diazole and as an alkaloid.
Derivatives of imidazole, called imidazoles, a common family heterocycles with sharing the 1,3-C3N2 ring, but varying substituents. This ring system is present in important biological building-blocks, such as histidine, and the related hormone histamine. Many drugs contain an imidazole ring, such as antifungal drugs and nitroimidazole.
Imidazole is a planar 5-membered ring. It exists in two equivalent tautomeric forms, because the proton can be located on either of the two nitrogen atoms. Imidazole is a highly polar compound, as evidenced by a calculated dipole of 3.61D. It is highly soluble in water. The compound is classified as aromatic due to the presence of a sextet of π-electrons, consisting of a pair of electrons from the protonated nitrogen atom and one from each of the remaining four atoms of the ring. Some resonance structures of imidazole are shown below:
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Imidazole
imidazole
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Aromatic Heterocycles II
The Brackeen Imidazole Synthesis
Imidazole
imidazole
Imidazole group antifungal mode of action
Mod-32 Lec-36 Oxazole, Imidazole and Thiazole Synthesis
Dicarbazine Imidazole Chemotherapy Side Effects
Imidazole Meaning
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Imidazole - Hydra
CMSL - Staff Interview with Darwin "Imidazole" Mach
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How to Pronounce Imidazole
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