BEZ235 or NVP-BEZ235 is an imidazoquinoline derivative and PI3K inhibitor being investigated as a possible cancer treatment.
It has been shown to be toxic to Waldenström's macroglobulinemia cells.
It was the first PI3K inhibitor to enter clinical trials, in 2006 (primary outcome results due in 2010).
KDE may refer to:
Dice (1925–1927) was an American Champion Thoroughbred racehorse. Bred by Harry Payne Whitney, he was purchased as a yearling by Gladys Mills Phipps who raced him under her Wheatley Stable banner.
After making a winning debut in an overnight race at Jamaica Racetrack in New York, Dice went on to win four straight important races for his age group. After a one-mile workout at Saratoga Race Course in preparation for the following weeks Saratoga Special Stakes, Dice suddenly began bleeding from the nostrils and died.
Dice was retrospectively voted co-winner with Reigh Count as the American Champion Two-Year-Old Colt for 1927, an award won by his sire Dominant in 1915.
Dice (2001) is a Canada/UK co-produced drama television mini-series. It was directed by Rachel Talalay and written by A. L. Kennedy and John Burnside, inspired by cult 70s novel The Dice Man by Luke Rhinehart.
Dice tells the story of charismatic psychology teacher, Glenn Taylor (Aidan Gillen), who manipulates people by teaching them how to live by the throw of a dice. When the small community is shattered by the death of student Sally Quine, Detective Patrick Styvesant (Martin Cummins) finds himself drawn deeper into a bizarre world where decisions are ruled by the dice. As Taylor's influence over the community deepens, Patrick also has his own demons to contend with as he battles alcoholism and his repressed homosexuality, all of which make him a perfect target for Taylor.
DragonFly BSD is a free and open source Unix-like operating system created as a fork of FreeBSD 4.8. Matthew Dillon, an Amiga developer in the late 1980s and early 1990s and a FreeBSD developer between 1994 and 2003, began work on DragonFly BSD in June 2003 and announced it on the FreeBSD mailing lists on 16 July 2003.
Dillon started DragonFly in the belief that the methods and techniques being adopted for threading and symmetric multiprocessing in FreeBSD 5 would lead to poor system performance and cause maintenance difficulties. He sought to correct these suspected problems within the FreeBSD project. Due to ongoing conflicts with other FreeBSD developers over the implementation of his ideas, his ability to directly change the FreeBSD codebase was eventually revoked. Despite this, the DragonFly BSD and FreeBSD projects still work together contributing bug fixes, driver updates, and other system improvements to each other.
Intended to be the logical continuation of the FreeBSD 4.x series, DragonFly's development has diverged significantly from FreeBSD's, including a new Light Weight Kernel Threads implementation (LWKT), a lightweight ports/messaging system, and feature-rich HAMMER file system. Many concepts planned for DragonFly were inspired by the AmigaOS operating system.
Vaz is a Portuguese language surname.
It may refer to:
The Lada 110 or VAZ-2110 is a compact car built by the Russian automaker AvtoVAZ from 1995 to 2009. It spawned two close derivatives: the Lada 111 estate and the Lada 112 hatchback.
The prototype of the Lada 110, known as the 300 series, was created in 1987 and optimized for aerodynamics in Zuffenhausen, Germany, in cooperation between AvtoVAZ and Porsche engineers. The first photos of the new compact car were published in the popular monthly magazine Za Rulem in November 1990, and the car itself was demonstrated at the AvtoVAZ Togliatti factory in 1991. Serial production was planned to start in the following year, but an economic crisis stalled the project and the first cars rolled off the assembly line only on June 27, 1995. The Lada 110 featured a 1.6 litre engine producing approximately 90 hp (67 kW). Production began with 8 valve, and subsequently, 16 valve motors. Overall, the car weighed around 1050 kilos (2315 lb). It had electric windows, trip computer, power steering, and galvanized body panels. Fuel-injected models were equipped with electronic engine management system. In early 2006, new taillights and a new dashboard were introduced.