- published: 09 Feb 2016
- views: 2269
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Antisense RNA mechanism - This lecture explains about the gene silencing mechanism mediated by antisense RNA technology.
Antisense RNA (asRNA) is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell. Some authors have used the term micRNA (mRNA-interfering complementary RNA) to refer to these RNAs but it is not widely used.[1]
Antisense RNA may be introduced into a cell to inhibit translation of a complementary mRNA by base pairing to it and physically obstructing the translation machinery.[2] This effect is therefore stoichiometric. An example of naturally occurring mRNA antisense mechanism is the hok/sok system of the E. coli R1 plasmid. Antisense RNA has long been thought of as a promising technique for disease therapy; the only such case to have reached the market is the drug fomivirsen. One commentator has characterized antisense RNA as one of "dozens of technologies that are gorgeous in concept, but exasperating in [commercialization]".[3] Generally, antisense RNA still lack effective design, biological activity, and efficient route of administration.[4]
The effects of antisense RNA are related with the effects of RNA interference (RNAi). The RNAi process, found only in eukaryotes, is initiated by double-stranded RNA fragments, which may be created by the expression of an anti-sense RNA followed by the base-pairing of the anti-sense strand to the target transcript.[5] Double-stranded RNA may be created by other mechanisms (including secondary RNA structure). The double-stranded RNA is cleaved into small fragements by DICER, and then a single strand of the fragment is incorporated into the RNA-induced silencing complex (RISC) so that the RISC may bind to and degrade the complementary mRNA target.[6] Some genetically engineered transgenic plants that express antisense RNA do activate the RNAi pathway.[7] This processes resulted in differing magnitudes of gene silencing induced by the expression of antisense RNA. Well-known examples include the Flavr Savr tomato and two cultivars of ringspot-resistant papaya.[8][9]
Transcription of longer cis-antisense transcripts is a common phenomenon in the mammalian transcriptome.[10] Although the function of some cases have been described, such as the Zeb2/Sip1 antisense RNA, no general function has been elucidated. In the case of Zeb2/Sip1,[11] the antisense noncoding RNA is opposite the 5' splice site of an intron in the 5'UTR of the Zeb2 mRNA. Expression of the antisense ncRNA prevents splicing of an intron that contains a ribosome entry site necessary for efficient expression of the Zeb2 protein. Transcription of long antisense ncRNAs is often concordant with the associated protein-coding gene,[12] but more detailed studies have revealed that the relative expression patterns of the mRNA and antisense ncRNA are complex.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
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Thank you for watching
Lecture explaining Antisense RNA technology-
http://shomusbiology.weebly.com/
Download the study materials here-
http://shomusbiology.weebly.com/bio-materials.html
The application of Antisense RNA technology is in many sectors. This technology was used in Flavr Savr, for tomato ripening; ripening in tomato produces enzyme Polygalactourodase (PG) which softens tomatoes and finally rotten them quickly. Two biotechnology companies: Calgene, USA and ICI Seeds, UK introduced a gene in plant which synthesizes a complementary mRNA to PG gene and inhibites the synthesis of PG enzyme delaying over ripening and rotting. Antisense therapy is considered for treating certain genetic disorders and infections. This is also referred to as Gene Therapy. It includes: isolation of specific gene; it's cloning and inserting it into target tissue cells to make desired protein. It has to be ensured that the gene is expressed correctly and sufficiently without causing harm to patient in context with the immune response. Antisense RNA technology is also used for cancer therapy. This therapy is used for treating brain cancer -- malignant glioma and cancer of prostate gland, in malignant glioma IGF-I was over produced and in the prostate cancer IGF-IR was synthesized more. These two were used to block the translation. Research is carried on in regard with Antisense RNA drugs for treatment of CMV, HIV, cancer, etc. Antisense antiviral drug named Formivirsen is developed to treat CMV, which was licensed by FDA in August 1998. In 2010, scientist at NIPGR by using Antisense technology developed tomato which could last longer for more than 30 days by silencing two genes (alpha - man and beta -- hex) which causes softening and wrinkling in tomatoes during ripening process. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia.
Link- http://en.wikipedia.org/wiki/Main_Page Animation source: University of Nebraska. Copyright 2000. All the credit goes to the original content developer.
Link: http://passel.unl.edu/communities/index.php?idcollectionmodule=1130274210&allanims;=1
- published: 13 Mar 2013
- views: 21745
In genetics, a sense strand, or coding strand, is the segment of double-stranded DNA running from 5' to 3' that is complementary to the antisense strand of DNA, which runs from 3' to 5'. The sense strand is the strand of DNA that has the same sequence as the mRNA, which takes the antisense strand as its template during transcription, and eventually undergoes (typically, not always) translation into a protein.
The immediate product of this transcription is a resultant initial RNA transcript, which contains sequencing of nucleotides that are identical to the sense strand. The exception to this is that uracil is used for nucleotide sequencing of RNA molecules rather than thymine.
Most eukaryotic RNA transcripts undergo additional editing prior to being translated for protein synthesis. This process typically involves removal of introns from the initial RNA transcript, the addition of a methylated guanine nucleotide cap at the 5' end, and the addition of a poly-A tail at the 3' end. This deletion process is known as splicing. The end product is known as a mature mRNA. Prokaryotic mRNA does not undergo the same process.
Strictly speaking, only the mRNA makes "sense" with the genetic code, as the translated protein peptide sequence can be directly inferred from this strand. The "antisense" strand of DNA is complementary to the "sense" strand and is the actual template for mRNA synthesis.
Knowing the difference between the sense and antisense strands is important in certain molecular biology applications. For example, in microarray expression technologies, it is important to know which strand is "viewed" on the array. An array can correspond to either strand; however, a single array will be made entirely of "sense" or "antisense" strands.
Identifying the different strands is also important in understanding small interfering RNAs, or siRNA.
- published: 17 Oct 2013
- views: 17049
Find out more about biotech startups:
http://www.cast-pharma.com/pharma-biotech-marketing-solutions/?ref=yt
Animated slide deck for a clinical stage compound
This investigational compound uses a very new approach in the treatment of arteriosclerosis: it directly interacts with the RNA of a target protein. By mimicking a natural regulatory mechanism, it interferes very early in the pathological cascade. Our client, a biotech startup, was searching for a visual tool to help him introduce this clinical stage compound and explain its mechanism of action. The two animated PowerPoint presentations we created helped him succeed in convincing key opinion leaders and training his internal staff.
To read the full case study, click here: http://www.cast-pharma.com/portfolio/antisense-technology/?ref=yt
- published: 20 Nov 2014
- views: 1491
RNA interference (RNAi) is an important process, used by many different organisms to regulate the activity of genes. This animation explains how RNAi works and introduces the two main players: small interfering RNAs (siRNAs) and microRNAs (miRNAs). We take you on an audio-visual journey, diving into a cell to show how genes are transcribed to make messenger RNA (mRNA) and how RNAi can silence specific mRNAs to stop them from making proteins. The animation is based on the latest research, to give you an up-to-date view.
If you'd like to know more about the structures and processes you see in this video, check out the accompanying slideshow: http://www.nature.com/nrg/multimedia/rnai/animation/index.html
Sponsor message (May 2014): Dharmacon RNAi products are now part of GE Healthcare. Learn more at http://www.GELifeSciences.com/Dharmacon
- published: 16 Dec 2011
- views: 466705
In dieser Folge der Kreidezeit erklären wir, wie Wissenschaftler mit der Antisense-technik die Expression unerwünschter Enzyme verhindern können.
Mehr Kreidezeiten gibt's unter www.kreidezeit.tv
- published: 07 Jan 2011
- views: 6401
This video explains difference between sense strand, antisense strand, coding strand, non-coding strand, template strand, non-template strand, plus strand and minus strand of DNA.
To view a blog post on this topic which can be your quick notes :) visit http://www.nowiknowblog.com/2016/04/sense-strand-and-antisense-strand-what.html
SUBSCRIBE TO THE CHANNEL FOR NEW VIDEO EVERY WEEK :)
http://www.youtube.com/c/NowIKnow13
Now I Know Blog: http://www.nowiknowblog.com
Facebook: https://www.facebook.com/nowiknow13
Twitter: https://twitter.com/rupalgogia
- published: 11 Aug 2015
- views: 1945
Gene Silencing - This lecture explains about the gene silencing mechanism by antisense RNA technology. Antisense RNA and RNA interference mechanisms are used to control the expression of desired genes in cell and it can be used to degrade target RNA so that the expression of proteins can be prevented.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website – www.shomusbiology.com
Facebook page- https://www.facebook.com/ShomusBiology/
Twitter - https://twitter.com/shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- https://plus.google.com/113648584982732129198
LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661
Youtube- https://www.youtube.com/user/TheFunsuman
Thank you for watching
- published: 15 Feb 2016
- views: 3521
Antisense RNA
Antisense RNA (asRNA) is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell. Some authors have used the term micRNA (mRNA-interfering complementary RNA) to refer to these RNAs but it is not widely used.
Antisense RNA may be introduced into a cell to inhibit translation of a complementary mRNA by base pairing to it and physically obstructing the translation machinery. This effect is therefore stoichiometric. An example of naturally occurring mRNA antisense mechanism is the hok/sok system of the E. coli R1 plasmid. Antisense RNA has long been thought of as a promising technique for disease therapy; the only such case to have reached the market is the drug fomivirsen. One commentator has characterized antisense RNA as one of "dozens of technologies that are gorgeous in concept, but exasperating in [commercialization]". Generally, antisense RNA still lack effective design, biological activity, and efficient route of administration.
This page contains text from Wikipedia, the Free Encyclopedia -
https://wn.com/Antisense_RNA
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
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11:08Antisense RNA Technology
Antisense RNA TechnologyAntisense RNA Technology
Antisense RNA mechanism - This lecture explains about the gene silencing mechanism mediated by antisense RNA technology. Antisense RNA (asRNA) is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell. Some authors have used the term micRNA (mRNA-interfering complementary RNA) to refer to these RNAs but it is not widely used.[1] Antisense RNA may be introduced into a cell to inhibit translation of a complementary mRNA by base pairing to it and physically obstructing the translation machinery.[2] This effect is therefore stoichiometric. An example of naturally occurring mRNA antisense mechanism is the hok/sok system of the E. coli R1 plasmid. Antisense RNA has long been thought of as a promising technique for disease therapy; the only such case to have reached the market is the drug fomivirsen. One commentator has characterized antisense RNA as one of "dozens of technologies that are gorgeous in concept, but exasperating in [commercialization]".[3] Generally, antisense RNA still lack effective design, biological activity, and efficient route of administration.[4] The effects of antisense RNA are related with the effects of RNA interference (RNAi). The RNAi process, found only in eukaryotes, is initiated by double-stranded RNA fragments, which may be created by the expression of an anti-sense RNA followed by the base-pairing of the anti-sense strand to the target transcript.[5] Double-stranded RNA may be created by other mechanisms (including secondary RNA structure). The double-stranded RNA is cleaved into small fragements by DICER, and then a single strand of the fragment is incorporated into the RNA-induced silencing complex (RISC) so that the RISC may bind to and degrade the complementary mRNA target.[6] Some genetically engineered transgenic plants that express antisense RNA do activate the RNAi pathway.[7] This processes resulted in differing magnitudes of gene silencing induced by the expression of antisense RNA. Well-known examples include the Flavr Savr tomato and two cultivars of ringspot-resistant papaya.[8][9] Transcription of longer cis-antisense transcripts is a common phenomenon in the mammalian transcriptome.[10] Although the function of some cases have been described, such as the Zeb2/Sip1 antisense RNA, no general function has been elucidated. In the case of Zeb2/Sip1,[11] the antisense noncoding RNA is opposite the 5' splice site of an intron in the 5'UTR of the Zeb2 mRNA. Expression of the antisense ncRNA prevents splicing of an intron that contains a ribosome entry site necessary for efficient expression of the Zeb2 protein. Transcription of long antisense ncRNAs is often concordant with the associated protein-coding gene,[12] but more detailed studies have revealed that the relative expression patterns of the mRNA and antisense ncRNA are complex. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching -
5:47Antisense RNA technology
Antisense RNA technologyAntisense RNA technology
Lecture explaining Antisense RNA technology- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html The application of Antisense RNA technology is in many sectors. This technology was used in Flavr Savr, for tomato ripening; ripening in tomato produces enzyme Polygalactourodase (PG) which softens tomatoes and finally rotten them quickly. Two biotechnology companies: Calgene, USA and ICI Seeds, UK introduced a gene in plant which synthesizes a complementary mRNA to PG gene and inhibites the synthesis of PG enzyme delaying over ripening and rotting. Antisense therapy is considered for treating certain genetic disorders and infections. This is also referred to as Gene Therapy. It includes: isolation of specific gene; it's cloning and inserting it into target tissue cells to make desired protein. It has to be ensured that the gene is expressed correctly and sufficiently without causing harm to patient in context with the immune response. Antisense RNA technology is also used for cancer therapy. This therapy is used for treating brain cancer -- malignant glioma and cancer of prostate gland, in malignant glioma IGF-I was over produced and in the prostate cancer IGF-IR was synthesized more. These two were used to block the translation. Research is carried on in regard with Antisense RNA drugs for treatment of CMV, HIV, cancer, etc. Antisense antiviral drug named Formivirsen is developed to treat CMV, which was licensed by FDA in August 1998. In 2010, scientist at NIPGR by using Antisense technology developed tomato which could last longer for more than 30 days by silencing two genes (alpha - man and beta -- hex) which causes softening and wrinkling in tomatoes during ripening process. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia. Link- http://en.wikipedia.org/wiki/Main_Page Animation source: University of Nebraska. Copyright 2000. All the credit goes to the original content developer. Link: http://passel.unl.edu/communities/index.php?idcollectionmodule=1130274210&allanims;=1 -
9:55Sense and antisense strands of DNA
Sense and antisense strands of DNASense and antisense strands of DNA
In genetics, a sense strand, or coding strand, is the segment of double-stranded DNA running from 5' to 3' that is complementary to the antisense strand of DNA, which runs from 3' to 5'. The sense strand is the strand of DNA that has the same sequence as the mRNA, which takes the antisense strand as its template during transcription, and eventually undergoes (typically, not always) translation into a protein. The immediate product of this transcription is a resultant initial RNA transcript, which contains sequencing of nucleotides that are identical to the sense strand. The exception to this is that uracil is used for nucleotide sequencing of RNA molecules rather than thymine. Most eukaryotic RNA transcripts undergo additional editing prior to being translated for protein synthesis. This process typically involves removal of introns from the initial RNA transcript, the addition of a methylated guanine nucleotide cap at the 5' end, and the addition of a poly-A tail at the 3' end. This deletion process is known as splicing. The end product is known as a mature mRNA. Prokaryotic mRNA does not undergo the same process. Strictly speaking, only the mRNA makes "sense" with the genetic code, as the translated protein peptide sequence can be directly inferred from this strand. The "antisense" strand of DNA is complementary to the "sense" strand and is the actual template for mRNA synthesis. Knowing the difference between the sense and antisense strands is important in certain molecular biology applications. For example, in microarray expression technologies, it is important to know which strand is "viewed" on the array. An array can correspond to either strand; however, a single array will be made entirely of "sense" or "antisense" strands. Identifying the different strands is also important in understanding small interfering RNAs, or siRNA. -
4:55RNA interference animation
RNA interference animationRNA interference animation
RNA interference -
3:01Difference between Sense Strand and Antisense Strand of DNA
Difference between Sense Strand and Antisense Strand of DNADifference between Sense Strand and Antisense Strand of DNA
This video explains Plus strand vs minus strand, coding vs non-coding strand, template vs non-template strand of DNA sense strand vs antisense strand of DNA For notes: http://www.majordifferences.com/2015/01/difference-between-sense-and-antisense.html -
0:43Antisense Technology
Antisense TechnologyAntisense Technology
Find out more about biotech startups: http://www.cast-pharma.com/pharma-biotech-marketing-solutions/?ref=yt Animated slide deck for a clinical stage compound This investigational compound uses a very new approach in the treatment of arteriosclerosis: it directly interacts with the RNA of a target protein. By mimicking a natural regulatory mechanism, it interferes very early in the pathological cascade. Our client, a biotech startup, was searching for a visual tool to help him introduce this clinical stage compound and explain its mechanism of action. The two animated PowerPoint presentations we created helped him succeed in convincing key opinion leaders and training his internal staff. To read the full case study, click here: http://www.cast-pharma.com/portfolio/antisense-technology/?ref=yt -
5:07RNA interference (RNAi): by Nature Video
RNA interference (RNAi): by Nature VideoRNA interference (RNAi): by Nature Video
RNA interference (RNAi) is an important process, used by many different organisms to regulate the activity of genes. This animation explains how RNAi works and introduces the two main players: small interfering RNAs (siRNAs) and microRNAs (miRNAs). We take you on an audio-visual journey, diving into a cell to show how genes are transcribed to make messenger RNA (mRNA) and how RNAi can silence specific mRNAs to stop them from making proteins. The animation is based on the latest research, to give you an up-to-date view. If you'd like to know more about the structures and processes you see in this video, check out the accompanying slideshow: http://www.nature.com/nrg/multimedia/rnai/animation/index.html Sponsor message (May 2014): Dharmacon RNAi products are now part of GE Healthcare. Learn more at http://www.GELifeSciences.com/Dharmacon -
1:25Kreidezeit 31: Antisense-Technik
Kreidezeit 31: Antisense-TechnikKreidezeit 31: Antisense-Technik
In dieser Folge der Kreidezeit erklären wir, wie Wissenschaftler mit der Antisense-technik die Expression unerwünschter Enzyme verhindern können. Mehr Kreidezeiten gibt's unter www.kreidezeit.tv -
8:03Sense Strand or Antisense Strand - What is the difference ???
Sense Strand or Antisense Strand - What is the difference ???Sense Strand or Antisense Strand - What is the difference ???
This video explains difference between sense strand, antisense strand, coding strand, non-coding strand, template strand, non-template strand, plus strand and minus strand of DNA. To view a blog post on this topic which can be your quick notes :) visit http://www.nowiknowblog.com/2016/04/sense-strand-and-antisense-strand-what.html SUBSCRIBE TO THE CHANNEL FOR NEW VIDEO EVERY WEEK :) http://www.youtube.com/c/NowIKnow13 Now I Know Blog: http://www.nowiknowblog.com Facebook: https://www.facebook.com/nowiknow13 Twitter: https://twitter.com/rupalgogia -
16:47Gene Silencing mechanism
Gene Silencing mechanismGene Silencing mechanism
Gene Silencing - This lecture explains about the gene silencing mechanism by antisense RNA technology. Antisense RNA and RNA interference mechanisms are used to control the expression of desired genes in cell and it can be used to degrade target RNA so that the expression of proteins can be prevented. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching
-
Antisense RNA Technology
Antisense RNA mechanism - This lecture explains about the gene silencing mechanism mediated by antisense RNA technology. Antisense RNA (asRNA) is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell. Some authors have used the term micRNA (mRNA-interfering complementary RNA) to refer to these RNAs but it is not widely used.[1] Antisense RNA may be introduced into a cell to inhibit translation of a complementary mRNA by base pairing to it and physically obstructing the translation machinery.[2] This effect is therefore stoichiometric. An example of naturally occurring mRNA antisense mechanism is the hok/sok system of the E. coli R1 plasmid. Antisense RNA has long been thought of as a promising technique for disease therapy; the only such ca... -
Antisense RNA technology
Lecture explaining Antisense RNA technology- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html The application of Antisense RNA technology is in many sectors. This technology was used in Flavr Savr, for tomato ripening; ripening in tomato produces enzyme Polygalactourodase (PG) which softens tomatoes and finally rotten them quickly. Two biotechnology companies: Calgene, USA and ICI Seeds, UK introduced a gene in plant which synthesizes a complementary mRNA to PG gene and inhibites the synthesis of PG enzyme delaying over ripening and rotting. Antisense therapy is considered for treating certain genetic disorders and infections. This is also referred to as Gene Therapy. It includes: isolation of specific gene; it's cloning... -
Sense and antisense strands of DNA
In genetics, a sense strand, or coding strand, is the segment of double-stranded DNA running from 5' to 3' that is complementary to the antisense strand of DNA, which runs from 3' to 5'. The sense strand is the strand of DNA that has the same sequence as the mRNA, which takes the antisense strand as its template during transcription, and eventually undergoes (typically, not always) translation into a protein. The immediate product of this transcription is a resultant initial RNA transcript, which contains sequencing of nucleotides that are identical to the sense strand. The exception to this is that uracil is used for nucleotide sequencing of RNA molecules rather than thymine. Most eukaryotic RNA transcripts undergo additional editing prior to being translated for protein synthesis. This p... -
RNA interference animation
RNA interference -
Difference between Sense Strand and Antisense Strand of DNA
This video explains Plus strand vs minus strand, coding vs non-coding strand, template vs non-template strand of DNA sense strand vs antisense strand of DNA For notes: http://www.majordifferences.com/2015/01/difference-between-sense-and-antisense.html -
Antisense Technology
Find out more about biotech startups: http://www.cast-pharma.com/pharma-biotech-marketing-solutions/?ref=yt Animated slide deck for a clinical stage compound This investigational compound uses a very new approach in the treatment of arteriosclerosis: it directly interacts with the RNA of a target protein. By mimicking a natural regulatory mechanism, it interferes very early in the pathological cascade. Our client, a biotech startup, was searching for a visual tool to help him introduce this clinical stage compound and explain its mechanism of action. The two animated PowerPoint presentations we created helped him succeed in convincing key opinion leaders and training his internal staff. To read the full case study, click here: http://www.cast-pharma.com/portfolio/antisense-technology/?r... -
RNA interference (RNAi): by Nature Video
RNA interference (RNAi) is an important process, used by many different organisms to regulate the activity of genes. This animation explains how RNAi works and introduces the two main players: small interfering RNAs (siRNAs) and microRNAs (miRNAs). We take you on an audio-visual journey, diving into a cell to show how genes are transcribed to make messenger RNA (mRNA) and how RNAi can silence specific mRNAs to stop them from making proteins. The animation is based on the latest research, to give you an up-to-date view. If you'd like to know more about the structures and processes you see in this video, check out the accompanying slideshow: http://www.nature.com/nrg/multimedia/rnai/animation/index.html Sponsor message (May 2014): Dharmacon RNAi products are now part of GE Healthcare. Le... -
Kreidezeit 31: Antisense-Technik
In dieser Folge der Kreidezeit erklären wir, wie Wissenschaftler mit der Antisense-technik die Expression unerwünschter Enzyme verhindern können. Mehr Kreidezeiten gibt's unter www.kreidezeit.tv -
Sense Strand or Antisense Strand - What is the difference ???
This video explains difference between sense strand, antisense strand, coding strand, non-coding strand, template strand, non-template strand, plus strand and minus strand of DNA. To view a blog post on this topic which can be your quick notes :) visit http://www.nowiknowblog.com/2016/04/sense-strand-and-antisense-strand-what.html SUBSCRIBE TO THE CHANNEL FOR NEW VIDEO EVERY WEEK :) http://www.youtube.com/c/NowIKnow13 Now I Know Blog: http://www.nowiknowblog.com Facebook: https://www.facebook.com/nowiknow13 Twitter: https://twitter.com/rupalgogia -
Gene Silencing mechanism
Gene Silencing - This lecture explains about the gene silencing mechanism by antisense RNA technology. Antisense RNA and RNA interference mechanisms are used to control the expression of desired genes in cell and it can be used to degrade target RNA so that the expression of proteins can be prevented. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so th...
Antisense RNA Technology
- Order: Reorder
- Duration: 11:08
- Updated: 09 Feb 2016
- views: 2269
Antisense RNA mechanism - This lecture explains about the gene silencing mechanism mediated by antisense RNA technology.
Antisense RNA (asRNA) is a single-stran...
Antisense RNA mechanism - This lecture explains about the gene silencing mechanism mediated by antisense RNA technology.
Antisense RNA (asRNA) is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell. Some authors have used the term micRNA (mRNA-interfering complementary RNA) to refer to these RNAs but it is not widely used.[1]
Antisense RNA may be introduced into a cell to inhibit translation of a complementary mRNA by base pairing to it and physically obstructing the translation machinery.[2] This effect is therefore stoichiometric. An example of naturally occurring mRNA antisense mechanism is the hok/sok system of the E. coli R1 plasmid. Antisense RNA has long been thought of as a promising technique for disease therapy; the only such case to have reached the market is the drug fomivirsen. One commentator has characterized antisense RNA as one of "dozens of technologies that are gorgeous in concept, but exasperating in [commercialization]".[3] Generally, antisense RNA still lack effective design, biological activity, and efficient route of administration.[4]
The effects of antisense RNA are related with the effects of RNA interference (RNAi). The RNAi process, found only in eukaryotes, is initiated by double-stranded RNA fragments, which may be created by the expression of an anti-sense RNA followed by the base-pairing of the anti-sense strand to the target transcript.[5] Double-stranded RNA may be created by other mechanisms (including secondary RNA structure). The double-stranded RNA is cleaved into small fragements by DICER, and then a single strand of the fragment is incorporated into the RNA-induced silencing complex (RISC) so that the RISC may bind to and degrade the complementary mRNA target.[6] Some genetically engineered transgenic plants that express antisense RNA do activate the RNAi pathway.[7] This processes resulted in differing magnitudes of gene silencing induced by the expression of antisense RNA. Well-known examples include the Flavr Savr tomato and two cultivars of ringspot-resistant papaya.[8][9]
Transcription of longer cis-antisense transcripts is a common phenomenon in the mammalian transcriptome.[10] Although the function of some cases have been described, such as the Zeb2/Sip1 antisense RNA, no general function has been elucidated. In the case of Zeb2/Sip1,[11] the antisense noncoding RNA is opposite the 5' splice site of an intron in the 5'UTR of the Zeb2 mRNA. Expression of the antisense ncRNA prevents splicing of an intron that contains a ribosome entry site necessary for efficient expression of the Zeb2 protein. Transcription of long antisense ncRNAs is often concordant with the associated protein-coding gene,[12] but more detailed studies have revealed that the relative expression patterns of the mRNA and antisense ncRNA are complex.
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wn.com/Antisense Rna Technology
Antisense RNA mechanism - This lecture explains about the gene silencing mechanism mediated by antisense RNA technology.
Antisense RNA (asRNA) is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell. Some authors have used the term micRNA (mRNA-interfering complementary RNA) to refer to these RNAs but it is not widely used.[1]
Antisense RNA may be introduced into a cell to inhibit translation of a complementary mRNA by base pairing to it and physically obstructing the translation machinery.[2] This effect is therefore stoichiometric. An example of naturally occurring mRNA antisense mechanism is the hok/sok system of the E. coli R1 plasmid. Antisense RNA has long been thought of as a promising technique for disease therapy; the only such case to have reached the market is the drug fomivirsen. One commentator has characterized antisense RNA as one of "dozens of technologies that are gorgeous in concept, but exasperating in [commercialization]".[3] Generally, antisense RNA still lack effective design, biological activity, and efficient route of administration.[4]
The effects of antisense RNA are related with the effects of RNA interference (RNAi). The RNAi process, found only in eukaryotes, is initiated by double-stranded RNA fragments, which may be created by the expression of an anti-sense RNA followed by the base-pairing of the anti-sense strand to the target transcript.[5] Double-stranded RNA may be created by other mechanisms (including secondary RNA structure). The double-stranded RNA is cleaved into small fragements by DICER, and then a single strand of the fragment is incorporated into the RNA-induced silencing complex (RISC) so that the RISC may bind to and degrade the complementary mRNA target.[6] Some genetically engineered transgenic plants that express antisense RNA do activate the RNAi pathway.[7] This processes resulted in differing magnitudes of gene silencing induced by the expression of antisense RNA. Well-known examples include the Flavr Savr tomato and two cultivars of ringspot-resistant papaya.[8][9]
Transcription of longer cis-antisense transcripts is a common phenomenon in the mammalian transcriptome.[10] Although the function of some cases have been described, such as the Zeb2/Sip1 antisense RNA, no general function has been elucidated. In the case of Zeb2/Sip1,[11] the antisense noncoding RNA is opposite the 5' splice site of an intron in the 5'UTR of the Zeb2 mRNA. Expression of the antisense ncRNA prevents splicing of an intron that contains a ribosome entry site necessary for efficient expression of the Zeb2 protein. Transcription of long antisense ncRNAs is often concordant with the associated protein-coding gene,[12] but more detailed studies have revealed that the relative expression patterns of the mRNA and antisense ncRNA are complex.
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- published: 09 Feb 2016
- views: 2269
Antisense RNA technology
- Order: Reorder
- Duration: 5:47
- Updated: 13 Mar 2013
- views: 21745
Lecture explaining Antisense RNA technology-
http://shomusbiology.weebly.com/
Download the study materials here-
http://shomusbiology.weebly.com/bio-materials.h...
Lecture explaining Antisense RNA technology-
http://shomusbiology.weebly.com/
Download the study materials here-
http://shomusbiology.weebly.com/bio-materials.html
The application of Antisense RNA technology is in many sectors. This technology was used in Flavr Savr, for tomato ripening; ripening in tomato produces enzyme Polygalactourodase (PG) which softens tomatoes and finally rotten them quickly. Two biotechnology companies: Calgene, USA and ICI Seeds, UK introduced a gene in plant which synthesizes a complementary mRNA to PG gene and inhibites the synthesis of PG enzyme delaying over ripening and rotting. Antisense therapy is considered for treating certain genetic disorders and infections. This is also referred to as Gene Therapy. It includes: isolation of specific gene; it's cloning and inserting it into target tissue cells to make desired protein. It has to be ensured that the gene is expressed correctly and sufficiently without causing harm to patient in context with the immune response. Antisense RNA technology is also used for cancer therapy. This therapy is used for treating brain cancer -- malignant glioma and cancer of prostate gland, in malignant glioma IGF-I was over produced and in the prostate cancer IGF-IR was synthesized more. These two were used to block the translation. Research is carried on in regard with Antisense RNA drugs for treatment of CMV, HIV, cancer, etc. Antisense antiviral drug named Formivirsen is developed to treat CMV, which was licensed by FDA in August 1998. In 2010, scientist at NIPGR by using Antisense technology developed tomato which could last longer for more than 30 days by silencing two genes (alpha - man and beta -- hex) which causes softening and wrinkling in tomatoes during ripening process. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia.
Link- http://en.wikipedia.org/wiki/Main_Page Animation source: University of Nebraska. Copyright 2000. All the credit goes to the original content developer.
Link: http://passel.unl.edu/communities/index.php?idcollectionmodule=1130274210&allanims;=1
wn.com/Antisense Rna Technology
Lecture explaining Antisense RNA technology-
http://shomusbiology.weebly.com/
Download the study materials here-
http://shomusbiology.weebly.com/bio-materials.html
The application of Antisense RNA technology is in many sectors. This technology was used in Flavr Savr, for tomato ripening; ripening in tomato produces enzyme Polygalactourodase (PG) which softens tomatoes and finally rotten them quickly. Two biotechnology companies: Calgene, USA and ICI Seeds, UK introduced a gene in plant which synthesizes a complementary mRNA to PG gene and inhibites the synthesis of PG enzyme delaying over ripening and rotting. Antisense therapy is considered for treating certain genetic disorders and infections. This is also referred to as Gene Therapy. It includes: isolation of specific gene; it's cloning and inserting it into target tissue cells to make desired protein. It has to be ensured that the gene is expressed correctly and sufficiently without causing harm to patient in context with the immune response. Antisense RNA technology is also used for cancer therapy. This therapy is used for treating brain cancer -- malignant glioma and cancer of prostate gland, in malignant glioma IGF-I was over produced and in the prostate cancer IGF-IR was synthesized more. These two were used to block the translation. Research is carried on in regard with Antisense RNA drugs for treatment of CMV, HIV, cancer, etc. Antisense antiviral drug named Formivirsen is developed to treat CMV, which was licensed by FDA in August 1998. In 2010, scientist at NIPGR by using Antisense technology developed tomato which could last longer for more than 30 days by silencing two genes (alpha - man and beta -- hex) which causes softening and wrinkling in tomatoes during ripening process. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia.
Link- http://en.wikipedia.org/wiki/Main_Page Animation source: University of Nebraska. Copyright 2000. All the credit goes to the original content developer.
Link: http://passel.unl.edu/communities/index.php?idcollectionmodule=1130274210&allanims;=1
- published: 13 Mar 2013
- views: 21745
Sense and antisense strands of DNA
- Order: Reorder
- Duration: 9:55
- Updated: 17 Oct 2013
- views: 17049
In genetics, a sense strand, or coding strand, is the segment of double-stranded DNA running from 5' to 3' that is complementary to the antisense strand of DNA,...
In genetics, a sense strand, or coding strand, is the segment of double-stranded DNA running from 5' to 3' that is complementary to the antisense strand of DNA, which runs from 3' to 5'. The sense strand is the strand of DNA that has the same sequence as the mRNA, which takes the antisense strand as its template during transcription, and eventually undergoes (typically, not always) translation into a protein.
The immediate product of this transcription is a resultant initial RNA transcript, which contains sequencing of nucleotides that are identical to the sense strand. The exception to this is that uracil is used for nucleotide sequencing of RNA molecules rather than thymine.
Most eukaryotic RNA transcripts undergo additional editing prior to being translated for protein synthesis. This process typically involves removal of introns from the initial RNA transcript, the addition of a methylated guanine nucleotide cap at the 5' end, and the addition of a poly-A tail at the 3' end. This deletion process is known as splicing. The end product is known as a mature mRNA. Prokaryotic mRNA does not undergo the same process.
Strictly speaking, only the mRNA makes "sense" with the genetic code, as the translated protein peptide sequence can be directly inferred from this strand. The "antisense" strand of DNA is complementary to the "sense" strand and is the actual template for mRNA synthesis.
Knowing the difference between the sense and antisense strands is important in certain molecular biology applications. For example, in microarray expression technologies, it is important to know which strand is "viewed" on the array. An array can correspond to either strand; however, a single array will be made entirely of "sense" or "antisense" strands.
Identifying the different strands is also important in understanding small interfering RNAs, or siRNA.
wn.com/Sense And Antisense Strands Of Dna
In genetics, a sense strand, or coding strand, is the segment of double-stranded DNA running from 5' to 3' that is complementary to the antisense strand of DNA, which runs from 3' to 5'. The sense strand is the strand of DNA that has the same sequence as the mRNA, which takes the antisense strand as its template during transcription, and eventually undergoes (typically, not always) translation into a protein.
The immediate product of this transcription is a resultant initial RNA transcript, which contains sequencing of nucleotides that are identical to the sense strand. The exception to this is that uracil is used for nucleotide sequencing of RNA molecules rather than thymine.
Most eukaryotic RNA transcripts undergo additional editing prior to being translated for protein synthesis. This process typically involves removal of introns from the initial RNA transcript, the addition of a methylated guanine nucleotide cap at the 5' end, and the addition of a poly-A tail at the 3' end. This deletion process is known as splicing. The end product is known as a mature mRNA. Prokaryotic mRNA does not undergo the same process.
Strictly speaking, only the mRNA makes "sense" with the genetic code, as the translated protein peptide sequence can be directly inferred from this strand. The "antisense" strand of DNA is complementary to the "sense" strand and is the actual template for mRNA synthesis.
Knowing the difference between the sense and antisense strands is important in certain molecular biology applications. For example, in microarray expression technologies, it is important to know which strand is "viewed" on the array. An array can correspond to either strand; however, a single array will be made entirely of "sense" or "antisense" strands.
Identifying the different strands is also important in understanding small interfering RNAs, or siRNA.
- published: 17 Oct 2013
- views: 17049
RNA interference animation
- Order: Reorder
- Duration: 4:55
- Updated: 19 Oct 2009
- views: 20460
Difference between Sense Strand and Antisense Strand of DNA
- Order: Reorder
- Duration: 3:01
- Updated: 17 Jan 2015
- views: 17087
This video explains
Plus strand vs minus strand, coding vs non-coding strand, template vs non-template strand of DNA
sense strand vs antisense strand of DNA
Fo...
This video explains
Plus strand vs minus strand, coding vs non-coding strand, template vs non-template strand of DNA
sense strand vs antisense strand of DNA
For notes: http://www.majordifferences.com/2015/01/difference-between-sense-and-antisense.html
wn.com/Difference Between Sense Strand And Antisense Strand Of Dna
Antisense Technology
- Order: Reorder
- Duration: 0:43
- Updated: 20 Nov 2014
- views: 1491
Find out more about biotech startups:
http://www.cast-pharma.com/pharma-biotech-marketing-solutions/?ref=yt
Animated slide deck for a clinical stage compound
...
Find out more about biotech startups:
http://www.cast-pharma.com/pharma-biotech-marketing-solutions/?ref=yt
Animated slide deck for a clinical stage compound
This investigational compound uses a very new approach in the treatment of arteriosclerosis: it directly interacts with the RNA of a target protein. By mimicking a natural regulatory mechanism, it interferes very early in the pathological cascade. Our client, a biotech startup, was searching for a visual tool to help him introduce this clinical stage compound and explain its mechanism of action. The two animated PowerPoint presentations we created helped him succeed in convincing key opinion leaders and training his internal staff.
To read the full case study, click here: http://www.cast-pharma.com/portfolio/antisense-technology/?ref=yt
wn.com/Antisense Technology
Find out more about biotech startups:
http://www.cast-pharma.com/pharma-biotech-marketing-solutions/?ref=yt
Animated slide deck for a clinical stage compound
This investigational compound uses a very new approach in the treatment of arteriosclerosis: it directly interacts with the RNA of a target protein. By mimicking a natural regulatory mechanism, it interferes very early in the pathological cascade. Our client, a biotech startup, was searching for a visual tool to help him introduce this clinical stage compound and explain its mechanism of action. The two animated PowerPoint presentations we created helped him succeed in convincing key opinion leaders and training his internal staff.
To read the full case study, click here: http://www.cast-pharma.com/portfolio/antisense-technology/?ref=yt
- published: 20 Nov 2014
- views: 1491
RNA interference (RNAi): by Nature Video
- Order: Reorder
- Duration: 5:07
- Updated: 16 Dec 2011
- views: 466705
RNA interference (RNAi) is an important process, used by many different organisms to regulate the activity of genes. This animation explains how RNAi works and ...
RNA interference (RNAi) is an important process, used by many different organisms to regulate the activity of genes. This animation explains how RNAi works and introduces the two main players: small interfering RNAs (siRNAs) and microRNAs (miRNAs). We take you on an audio-visual journey, diving into a cell to show how genes are transcribed to make messenger RNA (mRNA) and how RNAi can silence specific mRNAs to stop them from making proteins. The animation is based on the latest research, to give you an up-to-date view.
If you'd like to know more about the structures and processes you see in this video, check out the accompanying slideshow: http://www.nature.com/nrg/multimedia/rnai/animation/index.html
Sponsor message (May 2014): Dharmacon RNAi products are now part of GE Healthcare. Learn more at http://www.GELifeSciences.com/Dharmacon
wn.com/Rna Interference (Rnai) By Nature Video
RNA interference (RNAi) is an important process, used by many different organisms to regulate the activity of genes. This animation explains how RNAi works and introduces the two main players: small interfering RNAs (siRNAs) and microRNAs (miRNAs). We take you on an audio-visual journey, diving into a cell to show how genes are transcribed to make messenger RNA (mRNA) and how RNAi can silence specific mRNAs to stop them from making proteins. The animation is based on the latest research, to give you an up-to-date view.
If you'd like to know more about the structures and processes you see in this video, check out the accompanying slideshow: http://www.nature.com/nrg/multimedia/rnai/animation/index.html
Sponsor message (May 2014): Dharmacon RNAi products are now part of GE Healthcare. Learn more at http://www.GELifeSciences.com/Dharmacon
- published: 16 Dec 2011
- views: 466705
Kreidezeit 31: Antisense-Technik
- Order: Reorder
- Duration: 1:25
- Updated: 07 Jan 2011
- views: 6401
In dieser Folge der Kreidezeit erklären wir, wie Wissenschaftler mit der Antisense-technik die Expression unerwünschter Enzyme verhindern können.
Mehr Kreidezei...
In dieser Folge der Kreidezeit erklären wir, wie Wissenschaftler mit der Antisense-technik die Expression unerwünschter Enzyme verhindern können.
Mehr Kreidezeiten gibt's unter www.kreidezeit.tv
wn.com/Kreidezeit 31 Antisense Technik
In dieser Folge der Kreidezeit erklären wir, wie Wissenschaftler mit der Antisense-technik die Expression unerwünschter Enzyme verhindern können.
Mehr Kreidezeiten gibt's unter www.kreidezeit.tv
- published: 07 Jan 2011
- views: 6401
Sense Strand or Antisense Strand - What is the difference ???
- Order: Reorder
- Duration: 8:03
- Updated: 11 Aug 2015
- views: 1945
This video explains difference between sense strand, antisense strand, coding strand, non-coding strand, template strand, non-template strand, plus strand and m...
This video explains difference between sense strand, antisense strand, coding strand, non-coding strand, template strand, non-template strand, plus strand and minus strand of DNA.
To view a blog post on this topic which can be your quick notes :) visit http://www.nowiknowblog.com/2016/04/sense-strand-and-antisense-strand-what.html
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wn.com/Sense Strand Or Antisense Strand What Is The Difference
This video explains difference between sense strand, antisense strand, coding strand, non-coding strand, template strand, non-template strand, plus strand and minus strand of DNA.
To view a blog post on this topic which can be your quick notes :) visit http://www.nowiknowblog.com/2016/04/sense-strand-and-antisense-strand-what.html
SUBSCRIBE TO THE CHANNEL FOR NEW VIDEO EVERY WEEK :)
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- published: 11 Aug 2015
- views: 1945
Gene Silencing mechanism
- Order: Reorder
- Duration: 16:47
- Updated: 15 Feb 2016
- views: 3521
Gene Silencing - This lecture explains about the gene silencing mechanism by antisense RNA technology. Antisense RNA and RNA interference mechanisms are used to...
Gene Silencing - This lecture explains about the gene silencing mechanism by antisense RNA technology. Antisense RNA and RNA interference mechanisms are used to control the expression of desired genes in cell and it can be used to degrade target RNA so that the expression of proteins can be prevented.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
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Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
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wn.com/Gene Silencing Mechanism
Gene Silencing - This lecture explains about the gene silencing mechanism by antisense RNA technology. Antisense RNA and RNA interference mechanisms are used to control the expression of desired genes in cell and it can be used to degrade target RNA so that the expression of proteins can be prevented.
For more information, log on to-
http://www.shomusbiology.com/
Get Shomu's Biology DVD set here-
http://www.shomusbiology.com/dvd-store/
Download the study materials here-
http://shomusbiology.com/bio-materials.html
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
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- published: 15 Feb 2016
- views: 3521
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11:08
Antisense RNA Technology
Antisense RNA mechanism - This lecture explains about the gene silencing mechanism mediate...
published: 09 Feb 2016
Antisense RNA Technology
Antisense RNA Technology
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- published: 09 Feb 2016
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5:47
Antisense RNA technology
Lecture explaining Antisense RNA technology-
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Download the...
published: 13 Mar 2013
Antisense RNA technology
Antisense RNA technology
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- published: 13 Mar 2013
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9:55
Sense and antisense strands of DNA
In genetics, a sense strand, or coding strand, is the segment of double-stranded DNA runni...
published: 17 Oct 2013
Sense and antisense strands of DNA
Sense and antisense strands of DNA
- Report rights infringement
- published: 17 Oct 2013
- views: 17049
4:55
RNA interference animation
RNA interference
published: 19 Oct 2009
RNA interference animation
RNA interference animation
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- published: 19 Oct 2009
- views: 20460
3:01
Difference between Sense Strand and Antisense Strand of DNA
This video explains
Plus strand vs minus strand, coding vs non-coding strand, template vs ...
published: 17 Jan 2015
Difference between Sense Strand and Antisense Strand of DNA
Difference between Sense Strand and Antisense Strand of DNA
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- published: 17 Jan 2015
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0:43
Antisense Technology
Find out more about biotech startups:
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published: 20 Nov 2014
Antisense Technology
Antisense Technology
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- published: 20 Nov 2014
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5:07
RNA interference (RNAi): by Nature Video
RNA interference (RNAi) is an important process, used by many different organisms to regul...
published: 16 Dec 2011
RNA interference (RNAi): by Nature Video
RNA interference (RNAi): by Nature Video
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- published: 16 Dec 2011
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1:25
Kreidezeit 31: Antisense-Technik
In dieser Folge der Kreidezeit erklären wir, wie Wissenschaftler mit der Antisense-technik...
published: 07 Jan 2011
Kreidezeit 31: Antisense-Technik
Kreidezeit 31: Antisense-Technik
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8:03
Sense Strand or Antisense Strand - What is the difference ???
This video explains difference between sense strand, antisense strand, coding strand, non-...
published: 11 Aug 2015
Sense Strand or Antisense Strand - What is the difference ???
Sense Strand or Antisense Strand - What is the difference ???
- Report rights infringement
- published: 11 Aug 2015
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16:47
Gene Silencing mechanism
Gene Silencing - This lecture explains about the gene silencing mechanism by antisense RNA...
published: 15 Feb 2016
Gene Silencing mechanism
Gene Silencing mechanism
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- published: 15 Feb 2016
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Antisense RNA Technology...
Antisense RNA technology...
Sense and antisense strands of DNA...
RNA interference animation...
Difference between Sense Strand and Antisense Stra...
Antisense Technology...
RNA interference (RNAi): by Nature Video...
Kreidezeit 31: Antisense-Technik...
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photo: US DoD / Air Force Tech. Sgt. Brigitte N. Brantley
Top US commander warns Russia, Syria
Edit CNN 21 Aug 2016
(CNN)In the most direct public warning to Moscow and Damascus to date, the new US commander of American troops in Iraq and Syria is vowing to defend US special operations forces in northern Syria if regime warplanes and artillery again attack in areas where troops are located. "We've informed the Russians where we're at ... Gen. Stephen Townsend told CNN in a telephone interview Saturday from his Baghdad headquarters ... Read More. RELATED ... ....
photo: AP / Gerald Herbert
'It's too late now to say sorry' : Clinton to Trump
Edit The Times of India 21 Aug 2016
NEW DELHI. Democratic US Presidential nominee Hillary Clinton on Sunday told her Republican opponent Donald Trump on Twitter that it was too late to apologize for the highly controversial remarks he's been making throughout his campaign ... "It's too late now to say sorry," Clinton's tweet reads. The accompanying video begins with a clip from the rally where Trump attempted to express regret for his past comments ... https.//t.co/TWj7QwEfVh....
photo: AP / Photo by Arthur Mola/Invision
Canadians bid adieu to beloved band whose singer is dying
Edit Springfield News-Sun 21 Aug 2016
The rock concert did not begin with a rock song. Instead, it started with flag-waving fans breaking into a national anthem, "O Canada.". The impromptu tribute by an emotional sold-out crowd that included Prime Minister Justin Trudeau began what was expected to be the final Saturday performance by the Tragically Hip, a group known as Canada's Band, and lead singer and songwriter Gord Downie, dubbed Canada's unofficial poet laureate ... ___....
photo: AP / Mahmut Bozarslan
Turkey's hit list of enemies is growing as Erdogan prepares to buddy up with Putin in Syria
Edit The Independent 21 Aug 2016
It says a lot about post-failed-coup Turkey that you can spot the priority list of President Recep Tayyip Erdogan’s foreign antagonists from the Government’s reactions to a massacre ... Erdogan said it was the “likely” culprit ... Read more ....
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Revolutionary method to map brains at single-neuron resolution successfully demonstrated
Edit Science Daily 20 Aug 2016
Neuroscientists have published details of a revolutionary new way of mapping the brain at the resolution of individual neurons, which they have successfully demonstrated in the mouse brain. It involves introducing unique RNA barcodes into individual neurons and later identifying these barcodes, via sequencing, in distant brain areas ... ....
Here's what aliens might actually look like
Edit Business Insider 20 Aug 2016
NASA/JPL-Caltech. Speculating about what aliens look like has kept children, film producers and scientists amused for decades. If they exist, will extra terrestrials turn out to look similar to us, or might they take a form beyond our wildest imaginings? ... Rerunning the tape of life ... For evolution to occur there needs to be some mechanism for storing and replicating information with moderate fidelity, such as DNA, RNA or some analogue ... ....
Week in Review: August 15–19
Edit The Scientist 19 Aug 2016
RNA-amplifying ribozyme. Researchers at the Scripps Research Institute in La Jolla, California, have used in vitro evolution to produce an RNA polymerase ribozyme that can synthesize functional RNAs and amplify short RNA templates ... Newly discovered amino acid reassignment could have implications for certain biotech applications and RNA-based evolutionary theories....
Some early birds might steal the worm (Colgate University)
Edit Public Technologies 19 Aug 2016
(Source. Colgate University) ... Researchers determined the daily RNA profile of circadian clock genes and identified individuals whose clocks cycled early (RNA larks) and late (owls) ... Results show that RNA-determined night owls are more than three times as likely to cheat on the matching test in the morning, compared to their early-bird peers, while early birds are more likely to cheat at night ... Related.. Nature (Scientific Reports) ... (noodl....
Study shows how mutations disrupt ALS-linked protein (Brown University)
Edit Public Technologies 19 Aug 2016
In general, TDP-43 acts like a chaperone for RNA in a cell, binding to it, guiding its processing, transporting it to where it needs to go and regulating it, so that other proteins can be expressed properly ... into little droplets, a process called 'liquid-liquid phase separation.' It's within these droplets that they could process and ferry RNA....
Neural Stem Cells Control their own Fate (Universität Basel)
Edit Public Technologies 19 Aug 2016
(Source. Universität Basel). To date, it has been assumed that the differentiation of stem cells depends on the environment they are embedded in ... Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons ... (noodl....
Intellia Therapeutics’ Preclinical Data Show Continued Progress in In Vivo Gene Editing With Systemic Lipid ...
Edit Nasdaq Globe Newswire 19 Aug 2016
This resulted in an associated decrease in serum TTR protein levels of up to approximately 80 percent;Dose-dependent editing by LNP delivery;Undetectable Cas9 mRNA and guide RNA (gRNA) in the liver at 72 hours post administration;Repair patterns in mouse liver cells in vivo being best predicted by primary mouse liver cells in vitro ... Study Background ... Various parameters were explored, including the nature of the guide RNA (sgRNA vs....
$58 Billion Life Science Tools and Reagents Market 2016 - Global Report 2015-2020
Edit Nasdaq Globe Newswire 19 Aug 2016
Dublin, Aug. 19, 2016 (GLOBE NEWSWIRE) -- Research and Markets has announced the addition of the "Life Science Tools and Reagents. Global Markets" report to their offering ... The tools and reagents covered in this report are used to conduct research in the domains of genomics (DNA and RNA research), proteomics, cell biology research, epigenetics, metabolomics, bioinformatics, imaging and microscopy and stem cell research ... Chapter 1 ... Fax....
Intellia Therapeutics’ Preclinical Data Show Continued Progress in In Vivo Gene Editing With Systemic Lipid Nanoparticle Delivery of CRISPR/Cas9 components (Intellia Therapeutics Inc)
Edit Public Technologies 19 Aug 2016
(Source ... (NASDAQ ... This resulted in an associated decrease in serum TTR protein levels of up to approximately 80 percent; Dose-dependent editing by LNP delivery; Undetectable Cas9 mRNA and guide RNA (gRNA) in the liver at 72 hours post administration; Repair patterns in mouse liver cells in vivo being best predicted by primary mouse liver cells in vitro ... Various parameters were explored, including the nature of the guide RNA (sgRNA vs....
Stanford scientists revise a decades-old model of how proteins move in cells (Stanford University)
Edit Public Technologies 19 Aug 2016
(Source. Stanford University). When things are going right in your body, it's because long strings of brand-new proteins are being folded up into just the right tangles and being delivered to just the right place within the cell at just the right time ... A protein's journey begins when a piece of messenger RNA delivers instructions and a command to a ribosome, one of the tiny bulbous protein factories within the cell ... (noodl. 35004527) ....
iCo Therapeutics Announces Second Quarter 2016 Financial Results
Edit Stockhouse 19 Aug 2016
Vancouver, British Columbia--(Newsfile Corp. - August 19, 2016) - iCo Therapeutics (TSXV. ICO) (OTCQX. ICOTF) ("iCo" or "the Company"), today reported financial results for the quarter ended June 30, 2016 ... Summary of Second Quarter 2016 Results ... dollar on iCo's cash balances ... Michael Liggett, CPA, CA, Bsc ... iCo-007 is a second generation antisense drug candidate targeting C-Raf kinase and iCo-008 is a monoclonal antibody targeting eotaxin-1....
Hemispherx Biopharma Forms Scientific Advisory Board to Provide Additional Scientific and Pharmaceutical Expertise
Edit Stockhouse 19 Aug 2016
PHILADELPHIA, Aug. 19, 2016 (GLOBE NEWSWIRE) -- Hemispherx Biopharma (NYSE MKT.HEB) announced that it has formed a scientific advisory board (SAB) ... Neal Burnette, Ph.D., and Christopher Nicodemus, M.D., F.A.C.P. Dr ... Dr ... Dr. Mitchell earned a M.D ... Dr ... Dr ... Dr ... Dr ... Dr ... Dr ... Ampligen® is an experimental RNA nucleic acid being developed for globally important debilitating diseases and disorders of the immune system, including Chronic Fatigue Syndrome ... ....
Hemispherx Biopharma Forms Scientific Advisory Board to Provide Additional Scientific and Pharmaceutical Expertise (Hemispherx Biopharma Inc)
Edit Public Technologies 19 Aug 2016
(Source. Hemispherx Biopharma Inc). PHILADELPHIA, Aug. 19, 2016 (GLOBE NEWSWIRE) -- Hemispherx Biopharma (NYSE MKT.HEB) announced that it has formed a scientific advisory board (SAB) ... The Board consists of William Mitchell, M.D., Ph.D., Ronald Brus, M.D., W ... Dr ... Ampligen® is an experimental RNA nucleic acid being developed for globally important debilitating diseases and disorders of the immune system, including Chronic Fatigue Syndrome....
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