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Purdue innovation uses faster, less-expensive method to discover two drugs that repurposed, could better treat bacterial, fungal infections (Purdue University)

Edit Public Technologies 10 Mar 2016
(Source. Purdue University). WEST LAFAYETTE, Ind ... Seleem said that through his research and studies he has identified two drugs, auranofin and ebselen, as a potent antimicrobial agent that is capable of killing intracellular Methicillin-resistant Staphylococcus aureus (MRSA), a bacterium responsible for several difficult-to-treat infections in humans. In addition, auranofin and ebselen also are exhibiting novel antifungal mechanisms....

Drug 'kills off ovarian cancer cells with BRCA mutation'

Edit The Daily Mail 08 Jan 2016
Plymouth University scientists found that auranofin, a drug typically used to treat rheumatoid arthritis, can help cut survival of cancerous ovarian cells in women with BRCA1 mutations, by 37 per cent ... ....

Metal-based compound to fight kidney cancer

Edit Yahoo Daily News 24 Sep 2015
"A gold based compound (called Auranofin) has been used to treat rheumatic diseases for years and has recently been used in clinical trials for the treatment of some cancers such as Chronic Lymphocytic Leukemia," study co-author Maria Contel, associate professor at Brooklyn College, The City University of New York, noted ... The findings appeared in the journal Chemical Science. ....

Metal-based compound shows promise for kidney cancer patients (University of Hawai?i at Manoa)

Edit Public Technologies 24 Sep 2015
(Source. University of Hawai?i at Manoa). Researchers have developed a promising metal-based compound that destroys kidney cancer cells, while leaving normal cells unharmed ... Said Dr ... Across the U.S ... Ramos ... Said Contel, "A gold-based compound (called Auranofin) has been used to treat rheumatic diseases for years and has recently been used in clinical trials for the treatment of some cancers such as Chronic Lymphocytic Leukemia ... (noodl....

Mānoa: Metal-based compound shows promise for kidney cancer patients (The University of Hawaii System)

Edit Public Technologies 24 Sep 2015
(Source. The University of Hawaii System). Researchers have developed a promising metal-based compound that destroys kidney cancer cells, while leaving normal cells unharmed ... Said Dr ... Across the U.S ... Ramos ... Said Contel, "A gold-based compound (called Auranofin) has been used to treat rheumatic diseases for years and has recently been used in clinical trials for the treatment of some cancers such as Chronic Lymphocytic Leukemia ... (noodl....

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

Edit PNAS 19 Mar 2015
From a cell-based screen for bactericidal compounds against Mycobacterium tuberculosis under nutrient-deprivation conditions we identified auranofin, an orally bioavailable FDA-approved antirheumatic drug, as having potent bactericidal activities against both replicating and nonreplicating M....

Research and Markets: Global Colitis Therapeutics Pipeline Review 2014 - Analysis of 16 Companies & 32 Drug Profiles

Edit Business Wire 29 Apr 2014
... Clostridium difficile Vaccine Cathelicidin IP-1510 Helminth-Derived Peptides Drugs to Inhibit Panx1 for Colitis Recombinant Cholera Toxin-B Bi-Specific Anti-TNFalpha/Ang2 Zybody auranofin NK-007 Treg Cells to Inhibit TCR Antagonist for Colitis Vaccine for Colitis and Respiratory Tract Inflammatory Disorders APY-0201 IL-23 P19 Vaccine AKB-6899 ....

Researchers Find Possible Golden Cure for ‘Baghdad Boil,’ Infection Afflicting Millions (University of Virginia)

Edit noodls 21 Feb 2014
By screening a relatively small library of existing drugs - a few thousand, rather than tens or hundreds of thousands - the researchers determined that the drug auranofin and potentially its derivatives are effective against leishmaniasis ... Auranofin is based on gold, but the researchers believe it would not be that expensive to produce for leishmaniasis treatment....

A Golden Cure for the 'Baghdad Boil'?

Edit Houston Chronicle 20 Feb 2014
By screening a relatively small library of existing drugs – a few thousand, rather than tens or hundreds of thousands – the researchers determined that the drug auranofin and potentially its derivatives are effective against leishmaniasis ... Auranofin is based on gold but the researchers believe it would not be that expensive to produce for leishmaniasis treatment....
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