Musepack or MPC is an open source lossy audio codec, specifically optimized for transparent compression of stereo audio at bitrates of 160–180 (manual set allows bitrates up to 320) kbit/s. It was formerly known as MPEGplus, MPEG+ or MP+.

Development of MPC was initiated in 1997 by Andree Buschmann and later assumed by Frank Klemm, and as of 2011 is maintained by the Musepack Development Team (MDT) with assistance from Buschmann and Klemm. Encoders and decoders are available for Microsoft Windows, Linux and Mac OS X, and plugins for several third-party media players available from the Musepack website, licensed under the GNU Lesser General Public License (LGPL) or BSD licenses, and an extensive list of programs supporting the format.

Musepack was developed using the MP2 codec as a starting point, but many features have since been added, including:

The psychoacoustic model of MPC is based on MPEG ISO model 2, but is extended by CVD (clear voice detection). The quantization algorithm of the MPC encoder performs spectral shaping of the noise, called adaptive noise shaping (ANS), in order to overcome the low frequency resolution of the polyphase quadrature filter bands.