Presser and comments from Nobel Prize winners
Baltimore, Maryland - 8
October 2003
1.
Nobel Prize winner
Peter Agre walking into lecture hall
2. Wide of lecture hall
3.
Cutaway of audience
4. SOUNDBITE (
English) Peter Agre,
Winner of
2003 Nobel Prize in Chemistry:
"I'd just like to
point out in all sincerity, and I am delighted this happened, but I feel at
Hopkins (
Johns Hopkins University School of Medicine) this could have happened to any of several of our colleagues.
And I feel kind of like the guy who just happened to be lucky enough to be up at bat when a fast ball got pitched down the middle. And so that's great, but it's part of the benefit of being at
Johns Hopkins. We have wonderful colleagues who have helped us with these studies, and I'm pleased that this has happened, and I'm very pleased particularly for Johns Hopkins."
5. Cutaway of audience
6. SOUNDBITE (English): Peter Agre, Winner of 2003 Nobel Prize in Chemistry
"No, I didn't have a plan that, you know, at age 16
I'll get a driver's license, at age 21 I'll graduate from college, get married, win a Nobel Prize, pay taxes and die. It just happened. If you see me trembling, there's a (inaudible) discharge here that I just can't overcome. I'm kind of excited, frankly."
7. Agre holding chart at podium
8.
Shot from behind podium of Agre speaking to audience
9. Agre at podium
New York, New York - Recent
FILE
10. Dr.
Roderick MacKinnon, Nobel Prize winner, speaking with lab technician
11.
Hands working on lab equipment
New York, New York - 8 October 2003
12. Dr. MacKinnon approaching and shaking hands with former
Nobel Prize winners, Dr.
Gunter Blobel and
Dr. Paul Greengard
13. Cutaway press, pan to Dr. MacKinnon and others
14.
Dr. MacKinnon entering building at
The Rockefeller University campus
15. SOUNDBITE (English) Dr. Roderick MacKinnon, Nobel Prize winner, chemistry:
"I didn't believe it at first, but it's wonderful. I'm so honoured."
(
Reporter question: What do you have planned for the money?)
"Well, I think I'd better buy a cellphone because there was a big communication problem this morning."
16. Dr. MacKinnon walking with students in front of press
New York, New York - Recent FILE
17. Wide of
Rockefeller University campus
18.
Entrance gate at The Rockefeller University campus
19. "The Rockefeller University"
sign
20.
Building at The Rockefeller University campus
STORYLINE:
Peter Agre and Roderick MacKinnon were awarded this year's Nobel Prize in Chemistry on Wednesday.
Agre, a professor of biological chemistry at the Johns Hopkins University School of Medicine in
Maryland, was awarded the the prize in recognition of his laboratory's
1991 discovery of the long-sought "channels" that regulate and facilitate water molecule transport through cell membranes, a process essential to all living organisms.
Agre (pronounced AHG-ray) shares this year's prize with MacKinnon, a Rockefeller University scientist who determined the spatial structure of cell membrane channels that control passage of salts.
The discovery of the water channel, dubbed "water pore" or aquaporin, ushered in a golden age of biochemical, physiological and genetic studies of these proteins in bacteria, plants and mammals, and fundamental understanding, at the molecular level, of malfunctioning channels associated with many diseases of the kidneys, skeletal muscle and other organs.
Working from this basic knowledge, scientists are searching for drugs that can specifically target water channel defects.
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