Frans Kaisiepo (October 10, 1921 – April 10, 1979) was a National Hero of Indonesia (Gelar Pahlawan Nasional Indonesia).

Kaisiepo was born in Wardo on the island of Biak on October 10, 1921. As the representative of Papua he was involved in the Malino Conference (16 July – 25 July 1946), where the formation of the Republic of Indonesia was discussed. He proposed the name Irian, which came from the Biak language.

He was educated at Sekolah Rakyat (Primary School) 1928–1931; LVVS Korido 1931-1934; Sekolah Guru Normalis at Manokwari 1934-1936; Bestuur Course, March – August 1945; and Bestuur School / Pamong Praja 1952-1954

He married Anthomina Arwam and had 3 children; however his wife died and then on 12 November 1973, he married Maria Magdalena Moorwahyuni from Demak, Central Java and they had one child.

The Japanese occupation of Indonesia during World War II resulted in the Dutch government lacking personnel in New Guinea. In order to satisfy this deficiency, in 1944, Resident J.P. van Eechoud established the Police Training School and the School of Civil Service (betuurschool) in Hollandia (currently Jayapura). Eechoud is often called "Vader der Papoea’s" (father of the Papuans). That school had taught 400 people between the year 1944 – 1949. It also produced the most intellectual Irians that were involved in the battle. The Indonesian declaration of independence on August 17, 1945 also affected many young learned men, among them Silas Papare, Albert Karubuy, and Marthen Indey. In 1946 in Serui, Silas Papare and a couple of his followers established a political pro-Indonesia organization called Irian Indonesian Independence Party or Partai Kemerdekaan Indonesia Irian (PKII).