The indigenous peoples of the Americas are the pre-Columbian inhabitants of North and South America and their descendants. Pueblos indígenas (indigenous peoples) is a common term in Spanish-speaking countries. Aborígen (aboriginal/native) is used in Argentina, while "Amerindian" is used in Guyana, but not commonly used in other countries. Indigenous peoples are known in Canada as Aboriginal peoples, and in the United States as Native Americans.

According to a prevailing New World migration model, migrations of humans from Eurasia to the Americas took place via Beringia, a land bridge which connected the two continents across what is now the Bering Strait. The most recent migration could have taken place around 12,000 years ago, with the earliest period remaining a matter of some unresolved contention. These early Paleo-Indians soon spread throughout the Americas, diversifying into many hundreds of culturally distinct nations and tribes. According to the oral histories of many of the indigenous peoples of the Americas, they have been living there since their genesis, described by a wide range of traditional creation accounts.

Indigenous peoples are ethnic groups that are defined as "indigenous" according to one of the various definitions of the term, though there is no universally accepted definition.

In the late twentieth century, the term began to be used primarily to refer to ethnic groups that have historical ties to groups that existed in a territory prior to colonization or formation of a nation state, and which normally preserve a degree of cultural and political separation from the mainstream culture and political system of the nation state within the border of which the indigenous group is located. The political sense of the term defines these groups as particularly vulnerable to exploitation and oppression by nation states. As a result, a special set of political rights in accordance with international law have been set forth by international organizations such as the United Nations, the International Labour Organization and the World Bank. The United Nations have issued a Declaration on the Rights of Indigenous Peoples to protect the collective rights of indigenous peoples to their culture, identity, language, employment, health, education and natural resources. Depending on which precise definition of "indigenous people" used, and on the census, estimates of a world total population of Indigenous people range from 220 million Indigenous peoples in 1997 to 350 million in 2004.

The Americas, or America, are lands in the Western hemisphere, also known as the New World.

In the English language, the Americas refers to the landmasses of North America and South America with their associated islands and regions, whereas America, in current usage, usually refers to the United States of America.

The Americas cover 8.3% of the Earth's total surface area (28.4% of its land area) and contain about 13.5% of the human population (about 900 million people).

The specifics of Paleo-Indian migration to and throughout the Americas, including the exact dates and routes traveled, are subject to ongoing research and discussion. The traditional theory has been that these early migrants moved into the Beringia land bridge between eastern Siberia and present-day Alaska around 40,000–17,000 years ago, when sea levels were significantly lowered due to the Quaternary glaciation. These people are believed to have followed herds of now-extinct pleistocene megafauna along ice-free corridors that stretched between the Laurentide and Cordilleran ice sheets. Another route proposed is that, either on foot or using primitive boats, they migrated down the Pacific Northwest coast to South America. Evidence of the latter would since have been covered by a sea level rise of hundreds of meters following the last ice age.