Abruzzo (pronounced [aˈbruttso]) is a region in Italy, its western border lying less than 50 miles (80 km) due east of Rome. Abruzzo borders the region of Marche to the north, Lazio to the west and south-west, Molise to the south-east, and the Adriatic Sea to the east. Although it is geographically more of a central than southern region, ISTAT (the Italian statistical authority) considers it part of Southern Italy, a vestige of Abruzzo's historic association with the Kingdom of the Two Sicilies.

The region is situated at the centre of the Italian peninsula facing the Adriatic, which it follows along 150 km of beaches and rocks. With an area of 10,763 km² (4,156 sq mi), and bordered on the east by the Adriatic and on the west by the Apennines, it is one of the most mountainous regions in Italy (the Corno Grande in the Gran Sasso massif, at 2,914 m (9,560.37 ft), is the highest summit in the Apennines). The rivers, although numerous, are all seasonal except for the biggest – the Pescara and the Sangro. In the interior are the 500 km² (190 sq mi) of the Abruzzo National Park, where rare examples of Mediterranean flora and fauna survive (chamois, wolves, bears, golden eagles).The climate is varied – warm and dry on the coast, an alpine climate in the mountainous interior. Major roads and railway lines link the region to the south, west and north of Italy and the rest of Europe.