Capsid

A capsid is the protein shell of a virus. It consists of several oligomeric structural subunits made of protein called protomers. The observable 3-dimensional morphological subunits, which may or may not correspond to individual proteins, are called capsomeres. The capsid encloses the genetic material of the virus.

Capsids are broadly classified according to their structure. The majority of viruses have capsids with either helical or icosahedral structure. Some viruses, such as bacteriophages, have developed more complicated structures due to constraints of elasticity and electrostatics. The icosahedral shape, which has 20 equilateral triangular faces, approximates a sphere, while the helical shape is cylindrical. The capsid faces may consist of one or more proteins. For example, the foot-and-mouth disease virus capsid has faces consisting of three proteins named VP1–3.

Some viruses are enveloped, meaning that the capsid is coated with a lipid membrane known as the viral envelope. The envelope is acquired by the capsid from an intracellular membrane in the virus' host; some examples would include the inner nuclear membrane, the golgi membrane, and the cell's outer membrane.

China Blocks US Navy Ships' Access to Hong Kong Port

Edit Voa News 30 Apr 2016

China has denied a U.S. Navy aircraft carrier access to a port in Hong Kong. The Pentagon said Friday the USS Stennis and its accompanying vessels were refused entry into the port. The reason for denying access to the port was not clear ... WATCH ... ....

photo: Creative Commons / Michael Vadon

Will easily defeat Hillary Clinton in November, says Donald Trump

Edit One India 30 Apr 2016

Washington, Apr 30. Nearly 250 delegates short of bagging the Republican presidential nomination, party front- runner Donald Trump has exuded confidence that he would be able to defeat his Democratic rival Hillary Clinton very easily in the November general elections. "Every ... ....

photo: AP / Matt Rourke

Emmanuel Rutema, 13, of Tanzania, rides an elevator before his surgery at the Shriners Hospital for Children in Philadelphia on Tuesday, June 30, 2015.

In Malawi, people with albinism face ‘total extinction’– UN rights expert

Edit United Nations 29 Apr 2016

Print. 29 April 2016 – A United Nations human rights expert today warned that the atrocities faced by persons with albinism in Malawi render them “an endangered people group facing a risk of systemic extinction over time if nothing is done.” ... “Many do not sleep peacefully and have deliberately restricted their movement to the necessary minimum,” she added ... ‘A crisis disturbing in its proportions’. Ms ... Ms ... Albinos. Photo ... Ms ... Ero stated....

photo: AP / Karim Kadim

Supporters of Shiite cleric Muqtada al-Sadr gather outside parliament in Baghdad's Green Zone, Saturday, April 30, 2016. Dozens of protesters climbed over the blast walls and could be seen storming the Parliament building, carrying Iraqi flags and chanting against the government.

State of emergency declared in Baghdad as protesters take Iraqi parliament

Edit Stars and Stripes 01 May 2016

BAGHDAD — A state of emergency was declared in the Iraqi capital on Saturday as protesters stormed Iraq's parliament, after bursting into the Baghdad's fortified Green Zone, where other key buildings including the U.S. Embassy are located, in a dramatic escalation of the country's political crisis ... Some lawmakers were berated and beaten with flags as they fled the building while other demonstrators smashed the car windows ... A U.S ... U.S ... ....

photo: AP / Peter Parks

Japan's Minister for Foreign Affairs, Fumio Kishida

China Says Japan Ties Should Be Based On Cooperation, Not Confrontation

Edit NDTV 30 Apr 2016

China's relations with Japan should be based on cooperation not confrontation, China's foreign minister told his Japanese counterpart today, adding that China would judge Japan's desire to improve tie... ....

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AGTC Announces Participation & Presentations at Upcoming Scientific & Investor Conferences

Edit Stockhouse 29 Apr 2016

Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) – Seattle, Wash. (May 1-5). William A ... (May 4-7). Terence R ... - 12.00 p.m. EDT on May 4th ... AGTC has a significant intellectual property portfolio and expertise in the design of gene therapy products including capsids, promoters and expression cassettes, as well as expertise in the formulation, manufacture and physical delivery of gene therapy products ... T....

AGTC Announces Participation & Presentations at Upcoming Scientific & Investor Conferences (Applied Genetic Technologies Corp)

Edit Public Technologies 29 Apr 2016

(Source. Applied Genetic Technologies Corp) ... Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) - Seattle, Wash. (May 1-5). William A ... PDT on May 3 ... AGTC has a significant intellectual property portfolio and expertise in the design of gene therapy products including capsids, promoters and expression cassettes, as well as expertise in the formulation, manufacture and physical delivery of gene therapy products....

AGTC to Host Third Quarter Financial Results Conference Call and Webcast on May 9, 2016

Edit Stockhouse 28 Apr 2016

AGTC management will host a conference call beginning at 5.00 pm Eastern Time that day to review results and provide a corporate update ... The passcode is 8570746 ... AGTC has a significant intellectual property portfolio and extensive expertise in the design of gene therapy products including capsids, promoters and expression cassettes, as well as, expertise in the formulation, manufacture and physical delivery of gene therapy products ... T ... ....

AGTC to Host Third Quarter Financial Results Conference Call and Webcast on May 9, 2016 (Applied Genetic Technologies Corp)

Edit Public Technologies 28 Apr 2016

(Source. Applied Genetic Technologies Corp) ... To access the call, dial 888-481-2877 (US) or 719-325-2455 (outside of the US). The passcode is 8570746 ... About AGTC ... AGTC has a significant intellectual property portfolio and extensive expertise in the design of gene therapy products including capsids, promoters and expression cassettes, as well as, expertise in the formulation, manufacture and physical delivery of gene therapy products ... T....

Arbutus Presents Data from Combination Activity Studies of HBV Drug Candidates

Edit Stockhouse 22 Apr 2016

... activity.That our first proprietary drug combination, RNAi plus capsid formation inhibitor, also demonstrates additive activity.These results support Arbutus’ combination strategy ... AB-423 (core protein/capsid inhibitor) with entecavir (EVT)In vitro and in vivo. AB-423 (core protein/capsid inhibitor) with ARB-1467 (RNAi)In vitro and in vivo....

Arbutus Presents Data from Combination Activity Studies of HBV Drug Candidates (Tekmira Pharmaceuticals Corporation)

Edit Public Technologies 22 Apr 2016

(Source. Tekmira Pharmaceuticals Corporation). April 22, 2016. Additional Preclinical Combination Data to be Presented This Year ... Sofia ... That our first proprietary drug combination, RNAi plus capsid formation inhibitor, also demonstrates additive activity ... Combination Study(ies). AB-423 (core protein/capsid inhibitor) with entecavir (EVT) In vitro and in vivo. AB-423 (core protein/capsid inhibitor) with ARB-1467 (RNAi) In vitro and in vivo....

AGTC Announces Data Evaluating Novel AAV-Based Gene Therapy as a Potential Treatment for Leber Congenital ...

Edit Stockhouse 22 Apr 2016

GAINESVILLE, Fla. and CAMBRIDGE, Mass., April 22, 2016 (GLOBE NEWSWIRE) -- Applied Genetic Technologies Corporation (Nasdaq ... About AGTC ... AGTC has a significant intellectual property portfolio and extensive expertise in the design of gene therapy products including capsids, promoters and expression cassettes, as well as, expertise in the formulation, manufacture and physical delivery of gene therapy products. Forward Looking Statements ... T....

AGTC Announces Data Evaluating Novel AAV-Based Gene Therapy as a Potential Treatment for Leber Congenital Amaurosis (LCA) and Severe Early-Childhood-Onset Retinal Degeneration (SECORD) (Applied Genetic Technologies Corp)

Edit Public Technologies 22 Apr 2016

(Source. Applied Genetic Technologies Corp). GAINESVILLE, Fla ... About AGTC ... AGTC has a significant intellectual property portfolio and extensive expertise in the design of gene therapy products including capsids, promoters and expression cassettes, as well as, expertise in the formulation, manufacture and physical delivery of gene therapy products. Forward Looking Statements ... IR/PR CONTACTS ... T ... (617) 413-2754 spotter@agtc.com ... (noodl....

AGTC Announces Publication of Safety and Biodistribution Data Supporting Future Clinical Studies of Novel Gene Therapy for Treating Achromatopsia (Applied Genetic Technologies Corp)

Edit Public Technologies 20 Apr 2016

(Source. Applied Genetic Technologies Corp) ... 'Currently there are no effective treatments for this disease ... This study in normal animals was not designed to evaluate efficacy ... AGTC has a significant intellectual property portfolio and expertise in the design of gene therapy products including capsids, promoters and expression cassettes, as well as expertise in the formulation, manufacture and physical delivery of gene therapy products ... T....

AGTC Announces Publication of Safety and Biodistribution Data Supporting Future Clinical Studies of Novel Gene ...

Edit Stockhouse 20 Apr 2016

“Currently there are no effective treatments for this disease ... This study in normal animals was not designed to evaluate efficacy ... About Achromatopsia ... About AGTC ... AGTC has a significant intellectual property portfolio and expertise in the design of gene therapy products including capsids, promoters and expression cassettes, as well as expertise in the formulation, manufacture and physical delivery of gene therapy products ... T ... ....

AGTC to Present at Upcoming Scientific Conferences (Applied Genetic Technologies Corp)

Edit Public Technologies 19 Apr 2016

(Source. Applied Genetic Technologies Corp). GAINESVILLE, Fla ... World Orphan Drug Congress - Washington, D.C. (April 20-22) ... (April 28-29) ... About AGTC ... AGTC has a significant intellectual property portfolio and extensive expertise in the design of gene therapy products including capsids, promoters and expression cassettes, as well as expertise in the formulation, manufacture and physical delivery of gene therapy products. IR/PR CONTACTS ... T....

Arbutus Presents Data on HBV Capsid Assembly Inhibitor AB-423 at EASL 2016

Edit Stockhouse 14 Apr 2016

VANCOUVER, British Columbia and DOYLESTOWN, Pa., April 14, 2016 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq.ABUS), an industry-leading Hepatitis B Virus (HBV) therapeutic solutions company, presented preclinical combination data on its potent core protein/ capsid assembly inhibitor, AB-423, at the European Association for the Study of the Liver (EASL) in Barcelona, Spain....

Arbutus Presents Data on HBV Capsid Assembly Inhibitor AB-423 at EASL 2016 (Tekmira Pharmaceuticals Corporation)

Edit Public Technologies 14 Apr 2016