Major League Soccer (MLS) is a professional soccer league based in the United States and sanctioned by the United States Soccer Federation (U.S. Soccer). The league is composed of 19 teams — 16 in the U.S. and 3 in Canada. MLS represents the top tier of both the American and Canadian soccer pyramids.

Major League Soccer was founded in 1993 as part of the United States' bid to host the 1994 FIFA World Cup. Unique for a major sports league, MLS operates under a single-entity structure, where each team is owned by the league and operated by its investors. The first season took place in 1996 beginning with 10 teams. Seasons presently run from March to December, with each team playing 34 games in the regular season. Ten teams compete in the postseason MLS Cup Playoffs culminating in the championship game, MLS Cup.

Major League Soccer's regular season runs from March to October with its 19 teams playing 34 games in an unbalanced schedule. Teams are divided into the Eastern and Western Conference. Midway through the season, teams break for the annual All-Star Game, a friendly game between the league's finest players and a major club from a different league. At the end of the regular season, the team with the highest point total is awarded the Supporters' Shield. The regular season is followed by the 10-team MLS Cup Playoffs ending with the MLS Cup championship final.

See Major professional sports leagues in the United States and Canada.

Major League may also refer to:

David Villa Sánchez (Spanish pronunciation: [daˈβið ˈβiʎa]; born 3 December 1981), nicknamed El Guaje (Asturian: The Kid), is a Spanish footballer who currently plays as a striker for FC Barcelona and the Spanish national football team. He can also operate as a winger.

Despite sustaining a serious injury as a child, he started his professional career with Sporting de Gijón. He moved to Real Zaragoza after two seasons, where he made his La Liga début, winning his first senior honours—the Copa del Rey and Supercopa de España. He joined Valencia CF in 2005 for a transfer fee of €12 million and was part of the Valencia team that won the Copa del Rey in the 2007–08 season. In 2010 he moved to FC Barcelona for €40 million where he won his first La Liga and UEFA Champions League titles.

Villa made his international début in 2005. He has since participated in three major tournaments, becoming an integral member of the Spain teams that won Euro 2008 and the 2010 World Cup. He scored three goals at the 2006 World Cup, was the top scorer at Euro 2008 and earned the Silver Boot at the 2010 World Cup. He is the first Spanish player to ever reach 50 international goals and is Spain's all-time top goalscorer, having has also scored more World Cup goals than any other player in Spain's history in the process. The goals-to-games ratio he has achieved for the national team has not been matched by any player since Alfredo Di Stéfano.