Etretinate
Etretinate (trade name Tegison) is a medication developed by Hoffmann–La Roche that was approved by the FDA in 1986 to treat severe psoriasis. It is a second-generation retinoid. It was subsequently removed from the Canadian market in 1996 and the United States market in 1998 due to the high risk of birth defects. It remains on the market in Japan as Tigason.
Pharmacology
Etretinate is a highly lipophilic, aromatic retinoid. It is stored and released from adipose tissue, so its effects can continue long after dosage stops. It is detectable in the plasma for up to three years following therapy. Etretinate has a low therapeutic index and a long elimination half-life (t1/2) of 120 days, which make dosing difficult.
Etretinate has been replaced by acitretin, the free acid (without the ethyl ester). While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body, so that it is still a long-acting teratogen and pregnancy is prohibited for two years after therapy.
Podcasts:
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by Tony T
Way To Rio
by: Tony TThe time in now yes man, so gather all your friends
and lets go.
feel the light of the morning sun, feet this, start
rejoising now everyone , ehh
follow me let me lead the way, in my hear is were you
will stay, yes.
Im on my way to rio thats were the sun always shines.
I'm on my way to rio so just place you hands in mine.
I'm on my way to rio love will leave know one behind.
I'm on my way to rio so just place your hand in mine
yes.
its the right time for having fun,yes, having fun yes,
party time underneath the sun yes
follow me let me lead the way, in my heart is were you
will stay.
Im on my way to rio thats were the sun always shines.
I'm on my way to rio so just place you hands in mine.
I'm on my way to rio love will leave know one behind.
I'm on my way to rio so just place your hand in mine
yes.
know more dark roads the sun will always shine so let
us gather together
and spread love one more time.
can you feel it its amazing
can you feel it its amazing
can you feel it its amazing
can you feel it its amazing
Im on my way to rio thats were the sun always shines
I'm on my way to rio so just place you hands in mine
I'm on my way to rio love will leave know one behind
I'm on my way to rio so just place your hand in mine