MEN1

Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome).

In vitro studies have shown that menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. However, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Two variants of the shorter transcript have been identified where alternative splicing affects the coding sequence. Five variants where alternative splicing takes place in the 5' UTR have also been identified.

History

In 1988, researchers at Uppsala University Hospital and the Karolinska Institute in Stockholm mapped the MEN1 gene to the long arm of chromosome 11. The gene was finally cloned in 1997.

Genomics

The gene is located on long arm of chromosome 11 (11q13) between base pairs 64,570,985 and 64,578,765. It has 10 exons and encodes a 610-amino acid protein.

Young (Kenny Chesney song)

"Young" is a song written by Naoise Sheridan, Steve McEwan and Craig Wiseman, and recorded by American country music singer Kenny Chesney. It was released in December 2001 as the lead single from his album No Shoes, No Shirt, No Problems. It peaked at number 2 on the U.S. Billboard Hot Country Singles & Tracks chart and at number 35 on the U.S. Billboard Hot 100 chart.

Content

The narrator reflects on what he did when he was in his teenage years.

Music video

The music video was Chesney's first of many videos that were by Shaun Silva and was released in January 2002. It was filmed in Sanford, Florida at the old bridge over the St. Johns River and on the banks of the river.

Chart positions

"Young" debuted at number 50 on the U.S. Billboard Hot Country Singles & Tracks chart for the week of December 29, 2001.

Year-end charts

References

External links

Young (surname)

The surname Young has several origins.

In some cases — particularly in England, Northern Ireland, and Scotland – the surname is derived from the Middle English yunge, yonge ("young"); This particular surname usually originated to distinguish a younger son.

In other cases, the surname is an Americanization of any number of like-sounding, or cognate surnames in other languages. For example: the German Jung and Junk; the Dutch Jong; and the French Lejeune and Lajeunesse. The surname can also be a form of the French Dion or Guyon.

In yet other cases, it is a romanization of Chinese Yang (楊/杨). Very rarely, it may be a romanization of the Korean surnames Yong (용; 龍) or Yeong (영; 永/榮/影); however, if seen in a Korean name, it is far more likely that Young is a portion of the given name instead.

Young is the 49th-most common surname in England; 22nd in Scotland and 11th in New Zealand.

Notable people with this surname include:

List of minor planets: 2001–3000

Fast5

Fast5 (originally called Fastnet) is a variation of netball featuring shortened games and goals worth multiple points. The new format was announced by the International Federation of Netball Associations (IFNA) in 2008, and was primarily developed for a new international competition, the Fast5 Netball World Series. The rules were revamped for 2012, with the variation being renamed Fast5.

Background

In 2008, the IFNA released the details of a new, faster format of netball, which eventually became known as "fastnet". The new format was developed for a new international netball competition, the World Netball Series. According to the IFNA, the new rules were ultimately designed to make games faster and more television-friendly, with the ultimate aim of raising the sport's profile and attracting more spectators and greater sponsorship. Previously, the new rules had been trialled by England junior and senior netball squads over a 12-month period. Some of the new rules were announced in December 2008, including six-minute playing quarters and power plays; others were announced in February 2009. The new format was quickly compared to Twenty20 cricket and rugby sevens.

Fast Five

Fast Five (alternatively known as Fast & Furious 5 or Fast & Furious 5: Rio Heist) is a 2011 American action film directed by Justin Lin and written by Chris Morgan. It is the fifth installment in The Fast and the Furious franchise. It was released first in Australia on April 20, 2011, and then in the United States on April 29, 2011. Fast Five follows Dominic Toretto (Vin Diesel), Brian O'Conner (Paul Walker), and Mia Toretto (Jordana Brewster) as they plan a heist to steal $100 million from corrupt businessman Hernan Reyes (Joaquim de Almeida) while being pursued for arrest by U.S. Diplomatic Security Service (DSS) agent Luke Hobbs (Dwayne Johnson).

When developing Fast Five, Universal Studios deliberately departed from the street racing theme prevalent in previous films in the series, to transform the franchise into a heist action series involving cars. By doing so, they hoped to attract wider audiences that might otherwise be put off by a heavy emphasis on cars and car culture. Fast Five is considered the transitional film in the series, featuring only one car race and giving more attention to action set pieces such as gun fights, brawls, and the heist of $100 million. The production mounted a comprehensive marketing campaign, marketing the film through social media, virtual games, cinema chains, automobile manufacturers, and at NASCAR races.

Drive (Béla Fleck album)

Drive is an album by American banjoist Béla Fleck. The album was produced toward the end of Fleck's New Grass Revival career and before the Flecktones were formed and included an all-star list of bluegrass performers.

Track listing

All tracks written by Béla Fleck

Bonus track on the SACD version*

Personnel

References