Semafo Inc. (TSX: SMF) is a mining company active in West Africa. Semafo operates active gold mines: at the Mana gold field in Burkina Faso, at Kiniero in Guinea, and at Samira Hill in Niger. In 2008 Semafo's operations produced some 195,500 ounces of gold. The company projected that in 2009, with the raising of Mana Mine's plant capacity to 6,000 tonnes per day of saprolite ore, their Burkina operations would account for 55% of their production. Total 2009 production for all three mines was projected at between 220,000 and 240,000 ounces of gold.

In addition to corporate facilities in Africa, Semafo has headquarters in Canada, in Saint Laurent, Quebec. The company is affiliated with Etruscan Resources, another Canadian-African mining company.