Persecution of Jews has occurred on numerous occasions and at widely different geographical locations. As well as being a major component in Jewish history, it has significantly affected the general history and social development of the countries and societies in which the persecuted Jews lived.

When Judea fell under the authority of the Seleucid Empire, the process of Hellenization was enforced by law. This effectively meant requiring pagan religious practice. In 167 BCE Jewish sacrifice was forbidden, sabbaths and feasts were banned and circumcision was outlawed. Altars to Greek gods were set up and animals prohibited to Jews were sacrificed on them. The Olympian Zeus was placed on the altar of the Temple. Possession of Jewish scriptures was made a capital offence.

In the Middle Ages Antisemitism in Europe was religious. Though not part of Roman Catholic dogma, many Christians, including members of the clergy, have held the Jewish people collectively responsible for killing Jesus, a practice originated by Melito of Sardis. As stated in the Boston College Guide to Passion Plays, "Over the course of time, Christians began to accept... that the Jewish people as a whole were responsible for killing Jesus. According to this interpretation, both the Jews present at Jesus Christ's death and the Jewish people collectively and for all time, have committed the sin of deicide, or God-killing. For 1900 years of Christian-Jewish history, the charge of deicide has led to hatred, violence against and murder of Jews in Europe and America."

The Jews (Hebrew: יְהוּדִים‎‎ ISO 259-3 Yhudim Israeli pronunciation [jehuˈdim]), also known as the Jewish people, are a nation and an ethnoreligious group, originating in the Israelites or Hebrews of the Ancient Near East. The Jewish ethnicity, nationality, and religion are strongly interrelated, as Judaism is the traditional faith of the Jewish nation.Converts to Judaism, whose status as Jews within the Jewish ethnos is equal to those born into it, have been absorbed into the Jewish people throughout the millennia.

In Jewish tradition, Jewish ancestry is traced to the Biblical patriarchs Abraham, Isaac and Jacob in the second millennium BCE. The modern State of Israel defines itself as a Jewish state in its Basic Laws, and Israel's Law of Return states: "Every Jew has the right to come to this country as an oleh." Israel is the only country where Jews are a majority of the population. Jews achieved political autonomy twice before in ancient history. The first of these periods lasted from 1350 to 586 BCE, and encompassed the periods of the Judges, the United Monarchy, and the Divided Monarchy of the Kingdoms of Israel and Judah, ending with the destruction of the First Temple. The second was the period of the Hasmonean Kingdom spanning from 140 to 37 BCE. Since the destruction of the First Temple, most Jews have lived in diaspora. A minority in every country in which they live (except Israel), they have frequently experienced persecution throughout history, resulting in a population that has fluctuated both in numbers and distribution over the centuries.

Cornelia "Corrie" ten Boom (Amsterdam, The Netherlands April 15, 1892 – Orange, California, April 15, 1983) was a Dutch Christian, who with her father and other family members helped many Jews escape the Nazi Holocaust during World War II. Her family was arrested due to an informant in 1944, and her father died 10 days later at Scheveningen prison. A sister, brother and nephew were released, but Corrie ten Boom and her sister Betsie were sent to Ravensbruck concentration camp, where Betsie died. Ten Boom wrote many books and spoke frequently in the post-war years about her experiences. She also aided Holocaust survivors in her native Holland. Her autobiography, The Hiding Place (1971) was later adapted as a film of the same name in 1973 and starred Jeannette Clift as ten Boom.

In 1940, the Nazis invaded the Netherlands. Among their restrictions was banning a club which ten Boom had run for young girls. In 1942, ten Boom and her family had become very active in the Dutch underground, hiding refugees. They rescued many Jews from the Nazi SS. They had long been involved in charitable work, and ten Boom had worked with disabled children. They believed the Jews were God's chosen people. They provided kosher food for the Jewish refugees who stayed with them and honored the Jewish Sabbath.