Llano Estacado (Spanish pronunciation: [ˈʝano estaˈkaðo], (meaning Palisaded Plains), commonly known as the Staked Plains, is a region in the Southwestern United States that encompasses parts of eastern New Mexico and northwestern Texas. One of the largest mesas or tablelands on the North American continent, the elevation rises from 3,000 feet (900 m) in the southeast to over 5,000 feet (1,500 m) in the northwest, sloping almost uniformly at about 10 feet per mile (1.9 m/km). At such a gradual slope, however, the elevation change is imperceptible to the human observer.

The Llano Estacado lies at the southern end of the High Plains section of the Great Plains of North America; it is part of what was once called the Great American Desert. The Canadian River forms the Llano's northern boundary, separating it from the rest of the High Plains. To the east, the Caprock Escarpment, a precipitous cliff about 300 feet (100 m) high, lies between the Llano and the red Permian plains of Texas; while to the west, the Mescalero Escarpment demarcates the edge of the Pecos River valley. The Llano has no natural southern boundary, instead blending into the Edwards Plateau near Big Spring, Texas. This geographic area stretches about 250 miles (400 km) north to south, and 150 miles (240 km) east to west, a total area of some 37,500 square miles (97,000 km²), larger than Indiana and 12 other states. It covers all or part of 33 Texas counties and four New Mexico counties.