Mandukhai Khatun (Mongolian: Мандухай хатан, Chinese: 满都海哈屯; pinyin: Mǎndūhǎi Hātún), also known as Mandukhai Sechen Khatun (Mongolian: Мандухай сэцэн хатан, or Queen Manduhai the Wise), (c. 1449 – 1510) was the Khatun of the Northern Yuan Dynasty or Post-Imperial Mongolia. She reunited the warring Mongols with her husband Batmunkh Dayan Khan.

Mandukhai was the only daughter of Chorosbai, chingsang (grand councillor) of the Ongud Mongols in eastern Mongolia. Her family were aristocrats. At the age of 18, Mandukhai was married to Manduul Khan, who ruled the Mongol Empire from 1473–1479, to whom she bore a daughter. Mandukhai then took precedence over Yekhe Khabartu Yungin, the childless first wife.

After the death of Manduul Khan in 1467 at the hands of his own advisor Eslem, a spy and an agent of Ming China, the throne was left without an heir. Mandukhai brought from hiding and adopted the seven year old orphan Batmunkh, son of the late Bayan Mongkhe Jonon, a direct descendant of Genghis Khan and part of the Altan Urug, who had also been killed by Eslem. As Batumunkh was the last living descendant of Genghis Khan, Mandukhai had him proclaimed Dayan Khan, and she rejected the marriage offer by General Unubold. However, Unubold, himself a descendant of Hasar, younger brother of Genghis Khan, remained loyal to Mandukhai and the child Khan.