Uraninite is a radioactive, uranium-rich mineral and ore with a chemical composition that is largely UO₂, but also contains UO₃ and oxides of lead, thorium, and rare earth elements. It is most commonly known as pitchblende (from pitch, because of its black color, and blende, a term used by German miners to denote minerals whose density suggested metal content, but whose exploitation was, at the time they were named, either impossible or not economically feasible). The mineral has been known at least since the 15th century from silver mines in the Ore Mountains, on the German/Czech border. The type locality is the town of Jáchymov, on the Czech side of the mountains, where F.E.Brückmann described the mineral in 1727. Pitchblende from the Johanngeorgenstadt deposit in Germany was used by M. Klaproth in 1789 to discover the element uranium.

All uraninite minerals contain a small amount of radium as a radioactive decay product of uranium. Uraninite also always contains small amounts of the lead isotopes ²⁰⁶Pb and ²⁰⁷Pb, the end products of the decay series of the uranium isotopes ²³⁸U and ²³⁵U respectively. Small amounts of helium are also present in uraninite as a result of alpha decay. Helium was first found on Earth in uraninite after having been discovered spectroscopically in the Sun's atmosphere. The extremely rare element technetium can be found in uraninite in very small quantities (about 0.2 ng/kg), produced by the spontaneous fission of uranium-238.